Preclinical study of innovative peptides mimicking the tertiary structure of the α-helix B of erythropoietin

IV Golubev, VV Gureev, MV Korokin, EA Serdyuk… - 2020 - cyberleninka.ru
Introduction: The aim of this study was to examine the effectiveness of innovative peptides
obtained by addition of polypeptide motifs with antiaggregation activity (Arg-Gly-Asp, Lys-Gly …

Correction of morphofunctional disturbances arising when modelling Preeclampsia with resveratrol and nicorandil

EG Stupakova, GA Lazareva… - Research Results in …, 2018 - cyberleninka.ru
Introduction: Preeclampsia is one of the most serious diseases of the second half of
pregnancy and is surely amongst the top three causes of maternal mortality. Therefore, the …

New approaches of morfofunktional pharmacological correction of violations of cardiovascular system in experimental preeclampsia

VV Gureev - Research Results in Pharmacology, 2016 - cyberleninka.ru
Experimental Modeling ADMA-like preeclampsia administration to rats was performed by
Nnitro-L-arginine methyl ester, from 14 to 20 days of pregnancy. The animals were observed …

Effect of GABA derivatives on the rate of thrombus formation, platelet aggregation, and plasma coagulation capacity in rats with experimental gestosis

IN Tyurenkov, VN Perfilova, VI Karamysheva… - Bulletin of Experimental …, 2014 - Springer
Experimental gestosis induced by replacement of drinking water with 1.8% NaCl promoted
hypercoagulation, increased the rate and degree of platelet aggregation, and reduced …

Long-term consequences of perinatal hypoxia and their possible pharmacological correction: responses of neocortical nerve cells and synapses

VA Otellin, LI Khozhai, TT Shishko… - Neuroscience and …, 2017 - Springer
The morphological characteristics of neurons and synaptic contacts in the neocortex
following acute perinatal hypoxia and subsequent use of Saliphene were studied in later …

The effect of humoral factors released by hypoperfused placenta on fetal development

VV Gureev, OY Antseferova, TI Lokteva… - Research Results in …, 2015 - cyberleninka.ru
Simulation of hypoperfusion of the right uterine horn in rats on the 14th day of pregnancy
resulted in disruption of microcirculation in placentas of the left uterine horn, decrease of …

Method development for quantitative determination of the gaba derivative solifen

LA Smirnova, AF Ryabukha, KA Kuznetsov… - Pharmaceutical …, 2020 - Springer
An HPLC method for quantitative determination of the new biologically active GABA
derivative Solifen was developed. The method sensitivity, compound retention time and UV …

Evaluation of DNA damage in experimental preeclampsia by comet assay

SA Kolesnikova, AI Eremina, MV Kustova… - … Biology and Medicine, 2018 - go.gale.com
Experimental preeclampsia induced by substitution of drinking water with 1.8% NaCl during
pregnancy was associated with an increase in the level of DNA damage in fetal brain and …

Structural Changes in the Elements of the Blood-Brain Barrier of the Hippocampus in Rats after Exposure to Perinatal Hypoxia and the Potential for Their …

VA Otellin, LI Khozhai, IN Tyurenkov… - Neuroscience and …, 2019 - Springer
Objectives. To study the dynamics of structural changes in elements of the blood-brain
barrier of the hippocampus during the early postnatal period and subsequent ontogeny after …

Long-term effects of perinatal hypoxic exposure on microvascular endothelium in the rat neocortex

VA Otellin, LI Khozhai, TT Shishko… - Journal of Evolutionary …, 2017 - Springer
The long-term effects of perinatal hypoxic exposure followed by the administration of salifen,
a GABA derivative, on morphological characteristics of the vascular wall elements in the …