Terpene synthases as metabolic gatekeepers in the evolution of plant terpenoid chemical diversity

PS Karunanithi, P Zerbe - Frontiers in plant science, 2019 - frontiersin.org
Terpenoids comprise tens of thousands of small molecule natural products that are widely
distributed across all domains of life. Plants produce by far the largest array of terpenoids …

Plant terpene specialized metabolism: complex networks or simple linear pathways?

ER Lanier, TB Andersen, B Hamberger - The Plant Journal, 2023 - Wiley Online Library
From the perspectives of pathway evolution, discovery and engineering of plant specialized
metabolism, the nature of the biosynthetic routes represents a critical aspect. Classical …

Plant specialized metabolism: diversity of terpene synthases and their products

ME Bergman, N Dudareva - Current Opinion in Plant Biology, 2024 - Elsevier
Terpenoids are ubiquitous to all kingdoms of life and are one of the most diverse groups of
compounds, both structurally and functionally. Despite being derived from common …

Plant terpenoid metabolism co-opts a component of the cell wall biosynthesis machinery

A Jozwiak, PD Sonawane, S Panda… - Nature Chemical …, 2020 - nature.com
Glycosylation is one of the most prevalent molecular modifications in nature. Single or
multiple sugars can decorate a wide range of acceptors from proteins to lipids, cell wall …

Recent progress and new perspectives for diterpenoid biosynthesis in medicinal plants

Z Hu, X Liu, M Tian, Y Ma, B Jin, W Gao… - Medicinal Research …, 2021 - Wiley Online Library
Abstract Diterpenoids, including more than 18,000 compounds, represent an important class
of metabolites that encompass both phytohormones and some industrially relevant …

Uncovering a miltiradiene biosynthetic gene cluster in the Lamiaceae reveals a dynamic evolutionary trajectory

AE Bryson, ER Lanier, KH Lau, JP Hamilton… - Nature …, 2023 - nature.com
The spatial organization of genes within plant genomes can drive evolution of specialized
metabolic pathways. Terpenoids are important specialized metabolites in plants with diverse …

Alternative metabolic pathways and strategies to high-titre terpenoid production in Escherichia coli

MA Rinaldi, CA Ferraz, NS Scrutton - Natural Product Reports, 2022 - pubs.rsc.org
Covering: up to 2021 Terpenoids are a diverse group of chemicals used in a wide range of
industries. Microbial terpenoid production has the potential to displace traditional …

A Cryptic Plant Terpene Cyclase Producing Unconventional 18‐ and 14‐Membered Macrocyclic C25 and C20 Terpenoids with Immunosuppressive Activity

YG Chen, DS Li, Y Ling, YC Liu, ZL Zuo… - Angewandte …, 2021 - Wiley Online Library
A versatile terpene synthase (LcTPS2) producing unconventional macrocyclic terpenoids
was characterized from Leucosceptrum canum. Engineered Escherichia coli and Nicotiana …

Early transcriptional response of terpenoid metabolism to Colletotrichum gloeosporioides in a resistant wild strawberry Fragaria nilgerrensis

N Mehmood, Y Yuan, M Ali, M Ali, J Iftikhar, C Cheng… - Phytochemistry, 2021 - Elsevier
Modern strawberry production is often threatened by microbe pathogens. Anthracnose is
among the most prominent fungal disease caused mainly by Colletotrichum gloeosporioides …

The biosynthesis of the anti‐microbial diterpenoid leubethanol in Leucophyllum frutescens proceeds via an all‐cis prenyl intermediate

GP Miller, WW Bhat, ER Lanier, SR Johnson… - The Plant …, 2020 - Wiley Online Library
Serrulatane diterpenoids are natural products found in plants from a subset of genera within
the figwort family (Scrophulariaceae). Many of these compounds have been characterized …