The elongation stage of transcription by RNA polymerase II (RNA Pol II) is central to the
regulation of gene expression in response to developmental and environmental cues in …

Transcription and replication both require large macromolecular complexes to act on a DNA
template, yet these machineries cannot simultaneously act on the same DNA sequence …

Background: Small cell lung cancer (SCLC) is an extremely aggressive cancer type with a
patient median survival of 6-12 months. Epidermal growth factor (EGF) signaling plays an …

MYC proto-oncogene dysregulation alters metabolism, translation, and other functions in
ways that support tumor induction and maintenance. Although Myc+/− mice are healthier …

MYC is a proto-oncogene that encodes a powerful regulator of transcription and cellular
programs essential for normal development, as well as the growth and survival of various …

In pancreatic ductal adenocarcinoma (PDAC), endogenous MYC is required for S-phase
progression and escape from immune surveillance. Here we show that MYC in PDAC cells …

Cancer comprises a heterogeneous disease, characterized by diverse features such as
constitutive expression of oncogenes and/or downregulation of tumor suppressor genes …

Replicative stress promotes genomic instability and tumorigenesis but also presents an
effective therapeutic endpoint, rationalizing detailed analysis of pathways that control DNA …

MYC, a key member of the Myc-proto-oncogene family, is a universal transcription amplifier
that regulates almost every physiological process in a cell including cell cycle, proliferation …

Whether phase-separation is involved in the organization of the transcriptional machinery
and if it aids or inhibits the transcriptional process is a matter of intense debate. In this Mini …