Targeting NMDA receptor complex in management of epilepsy
N-methyl-D-aspartate receptors (NMDARs) are widely distributed in the central nervous
system (CNS) and play critical roles in neuronal excitability in the CNS. Both clinical and …
system (CNS) and play critical roles in neuronal excitability in the CNS. Both clinical and …
[HTML][HTML] Sigma-1 receptor and seizures
E Vavers, L Zvejniece, M Dambrova - Pharmacological Research, 2023 - Elsevier
Over the last decade, sigma-1 receptor (Sig1R) has been recognized as a valid target for the
treatment of seizure disorders and seizure-related comorbidities. Clinical trials with Sig1R …
treatment of seizure disorders and seizure-related comorbidities. Clinical trials with Sig1R …
NMDA receptor C-terminal domain signalling in development, maturity, and disease
K Haddow, PC Kind, GE Hardingham - International Journal of Molecular …, 2022 - mdpi.com
The NMDA receptor is a Ca2+-permeant glutamate receptor which plays key roles in health
and disease. Canonical NMDARs contain two GluN2 subunits, of which 2A and 2B are …
and disease. Canonical NMDARs contain two GluN2 subunits, of which 2A and 2B are …
[HTML][HTML] Distinct regulation of tonic GABAergic inhibition by NMDA receptor subtypes
Tonic inhibition mediated by extrasynaptic GABA A Rs regulates various brain functions.
However, the mechanisms that regulate tonic inhibition remain largely unclear. Here, we …
However, the mechanisms that regulate tonic inhibition remain largely unclear. Here, we …
A Boron‐Chelating Piperazine‐Tethered Schiff Base Can Modulate Excitability in Brain Slices in a Specific Frequency Range
H Basoglu, İ Degirmencioglu, H Ozturk… - …, 2023 - Wiley Online Library
The ability of boron‐containing compounds to make various bonds with biological targets
draws attention in their use as new therapeutic agents. In this study, the effect of a newly …
draws attention in their use as new therapeutic agents. In this study, the effect of a newly …
[HTML][HTML] Autosomal Dominant Intellectual Development Disorder-6 (MRD6) Without Seizures Linked to a De Novo Mutation in the grin2b Gene Revealed by Exome …
H El Mouhi, M Abbassi, H Sayel, S Trhanint, A Natiq… - Cureus, 2023 - ncbi.nlm.nih.gov
Autosomal dominant intellectual development disorder-6 (MRD6) arises from a grin2b gene
mutation, inducing neurodevelopmental issues. The effects of MRD6 encompass cognitive …
mutation, inducing neurodevelopmental issues. The effects of MRD6 encompass cognitive …
Functional Analysis of NMDAR Subunit Components in Postsynaptic Currents of Identified Cells and Synapses in Brain Slices
L Pineau, N Burnashev - NMDA Receptors: Methods and Protocols, 2024 - Springer
Epilepsy is one of the most represented neurological diseases worldwide. However, in many
cases, the precise molecular mechanisms of epileptogenesis and ictiogenesis are unknown …
cases, the precise molecular mechanisms of epileptogenesis and ictiogenesis are unknown …
[5-Hidroksi-7-(Pentiloksi)-2-Fenil-4h-Kromen-4-One] molekülünün In Silico Özelliklerinin ve Beyin Dilimlerinde In-Vitro Epileptiform Aktivasyon Üzerine Etkilerinin …
Objective: Epilepsy is an incurable disorder, necessitating research into new drug
candidates. The molecule 5-hydroxy-7-(pentyloxy)-2-phenyl-4h-chromen-4-one …
candidates. The molecule 5-hydroxy-7-(pentyloxy)-2-phenyl-4h-chromen-4-one …
Transfection in Primary Cultured Neuronal Cells
KFM Marwick, GE Hardingham - NMDA Receptors: Methods and …, 2024 - Springer
Transfection allows the introduction of foreign nucleic acid into eukaryotic cells. It is an
important tool in understanding the roles of NMDARs in neurons. Here we describe using …
important tool in understanding the roles of NMDARs in neurons. Here we describe using …