Controlled anti-cancer drug release through advanced nano-drug delivery systems: Static and dynamic targeting strategies

FM Kashkooli, M Soltani, M Souri - Journal of controlled release, 2020 - Elsevier
Advances in nanomedicine, including early cancer detection, targeted drug delivery, and
personalized approaches to cancer treatment are on the rise. For example, targeted drug …

Ultrasound‐controlled drug release and drug activation for cancer therapy

L Tu, Z Liao, Z Luo, YL Wu, A Herrmann, S Huo - Exploration, 2021 - Wiley Online Library
Traditional chemotherapy suffers from severe toxicity and side effects that limit its maximum
application in cancer therapy. To overcome this challenge, an ideal treatment strategy would …

Ultrasound-mediated nano drug delivery for treating cancer: Fundamental physics to future directions

FM Kashkooli, A Jakhmola, TK Hornsby… - Journal of Controlled …, 2023 - Elsevier
The application of biocompatible nanocarriers in medicine has provided several benefits
over conventional treatment methods. However, achieving high treatment efficacy and deep …

External triggering and triggered targeting strategies for drug delivery

Y Wang, DS Kohane - Nature Reviews Materials, 2017 - nature.com
Drug delivery systems that are externally triggered to release drugs and/or target tissues
hold considerable promise for improving the treatment of many diseases by minimizing …

Doxil®—The first FDA-approved nano-drug: Lessons learned

YC Barenholz - Journal of controlled release, 2012 - Elsevier
Doxil®, the first FDA-approved nano-drug (1995), is based on three unrelated principles:(i)
prolonged drug circulation time and avoidance of the RES due to the use of PEGylated nano …

Treating metastatic cancer with nanotechnology

A Schroeder, DA Heller, MM Winslow… - Nature Reviews …, 2012 - nature.com
Metastasis accounts for the vast majority of cancer deaths. The unique challenges for
treating metastases include their small size, high multiplicity and dispersion to diverse organ …

The status of platinum anticancer drugs in the clinic and in clinical trials

NJ Wheate, S Walker, GE Craig, R Oun - Dalton transactions, 2010 - pubs.rsc.org
Since its approval in 1979 cisplatin has become an important component in chemotherapy
regimes for the treatment of ovarian, testicular, lung and bladder cancers, as well as …

State-of-the-art materials for ultrasound-triggered drug delivery

SR Sirsi, MA Borden - Advanced drug delivery reviews, 2014 - Elsevier
Ultrasound is a unique and exciting theranostic modality that can be used to track drug
carriers, trigger drug release and improve drug deposition with high spatial precision. In this …

Nanomaterials: applications in cancer imaging and therapy

JA Barreto, W O'Malley, M Kubeil, B Graham… - Advanced …, 2011 - Wiley Online Library
The application of nanomaterials (NMs) in biomedicine is increasing rapidly and offers
excellent prospects for the development of new non‐invasive strategies for the diagnosis …

Ultrasound-responsive nanocarriers in cancer treatment: A review

NS Awad, V Paul, NM AlSawaftah… - ACS Pharmacology & …, 2021 - ACS Publications
The safe and effective delivery of anticancer agents to diseased tissues is one of the
significant challenges in cancer therapy. Conventional anticancer agents are generally …