The β-lactams retain a central place in the antibacterial armamentarium. In Gram-negative
bacteria, β-lactamase enzymes that hydrolyze the amide bond of the four-membered β …

Infections of antibiotic-resistant pathogens pose an ever-increasing threat to mankind. The
investigation of novel approaches for tackling the antimicrobial resistance crisis must be part …

Bacterial infections, caused predominately by Gram-positive and Gram-negative organisms,
are proliferation of harmful strains of bacteria on or inside the body. Hospital-acquired and …

Advances in the field of boron chemistry have expanded the application of this element in
Medicinal Chemistry. Boron-containing compounds represent a new class for medicinal …

The bicyclic boronate VNRX-5133 (taniborbactam) is a new type of β-lactamase inhibitor in
clinical development. We report that VNRX-5133 inhibits serine-β-lactamases (SBLs) and …

Research related to boronic acids, from synthetic development to materials to drug
discovery, has skyrocketed in the past 20 years. In terms of drug discovery, the incorporation …

Infections caused by resistant bacteria are nowadays too common, and some pathogens
have even become resistant to multiple types of antibiotics, in which case few or even no …

Infect Dis Clin N Am 30 (2016) 441–464 http://dx. doi. org/10.1016/j. idc. 2016.02. 007 id.
theclinics. com 0891-5520/16/$–see front matter© 2016 Elsevier Inc. All rights reserved …

ABSTRACT QPX7728 is a new ultrabroad-spectrum inhibitor of serine and metallo-beta-
lactamases (MBLs) from a class of cyclic boronates that gave rise to vaborbactam. The …

The β-lactams are the most successful class of antibiotic drugs but they are vulnerable to
inactivation by a growing cadre of β-lactamases that now number more than a thousand …