Significance: Recent clinical evidence identified anemia to be correlated with severe
complications of cardiovascular disease (CVD) such as bleeding, thromboembolic events …

While red blood cell (RBC) transfusion is the most common medical intervention in
hospitalized patients, as with any therapeutic, it is not without risk. Allogeneic RBC exposure …

Enzymes catalyze biochemical reactions and play critical roles in human health and
disease. Enzyme variants and deficiencies can lead to variable expression of glycans, which …

A hemolytic transfusion reaction (HTR) is destruction of red cells due to immunologic
incompatibility between the donor and recipient. While current stringent compatibility testing …

Moderate anemia is associated with increased mortality and morbidity, including acute
kidney injury (AKI), in surgical patients. A red blood cell (RBC)-specific antibody model was …

Hemolytic transfusion reactions represent one of the most common causes of transfusion‐
related mortality. Although many factors influence hemolytic transfusion reactions …

Intravascular hemolysis is a hallmark of a large spectrum of diseases, including the sickle
cell disease (SCD), and is characterized by liberation of red blood cell (RBC) degradation …

Red blood cell (RBC) transfusion is a critical component of optimal management for a broad
range of conditions. Regardless of the indication, pretransfusion testing is required to …

Autoantibodies and alloantibodies can damage self-tissue or transplanted tissues through
either fixation of complement or ligation of FcγRs. Several pathways have been described …

Pulmonary arterial hypertension (PAH) is suspected to be a strong mortality determinant of
hemolytic disorders. However, direct contribution of acute intravascular hemolysis to fatal …