BACKGROUND Tertiary lymphoid structures (TLSs) are organized aggregates of immune
cells that form postnatally in nonlymphoid tissues. TLSs are not found under physiological …

Tertiary lymphoid structures (TLSs) are ectopic lymphoid organs that develop in non-
lymphoid tissues at sites of chronic inflammation including tumours. Key common …

Tertiary lymphoid structures (TLS) are transient ectopic lymphoid aggregates where
adaptive antitumour cellular and humoral responses can be elaborated. Initially described in …

Tertiary lymphoid structures (TLS) are transient ectopic lymphoid aggregates whose
formation might be caused by chronic inflammation states, such as cancer. However, how …

Lymph nodes (LNs) are strategically positioned at dedicated sites throughout the body to
facilitate rapid and efficient immunity. Central to the structural integrity and framework of LNs …

Although common evolutionary principles drive the growth of cancer cells regardless of the
tissue of origin, the microenvironment in which tumours arise substantially differs across …

In solid tumors, the presence of lymph node–like structures called tertiary lymphoid
structures (TLS) is associated with improved patient survival. However, little is known about …

The tumor microenvironment (TME) plays a central role in cancer development and
progression. It represents a complex network of cancer cell (sub-) clones and a variety of …

Lymph node stromal cells coordinate the adaptive immune response in secondary lymphoid
organs, providing both a structural matrix and soluble factors that regulate survival and …

Ectopic lymphoid structures form in a wide range of inflammatory conditions, including
infection, autoimmune disease, and cancer. In the context of infection, this response can be …