Metastasis to bone frequently occurs in majority of patients with advanced breast cancer and
prostate cancer, leading to devastating skeletal-related events and substantially reducing …

Oxidative stress (OS) is a chemical imbalance between an oxidant and an antioxidant,
causing damage to redox signaling and control or causing molecular damage. Unbalanced …

The interaction between circulating tumor cells and platelets is a key factor in cancer
metastasis. These interactions, driven by a variety of receptors, support circulating tumor …

Platelets are small anucleate cells that are traditionally described as the major effectors of
hemostasis and thrombosis. However, increasing evidence indicates that platelets play …

Tumor cells have the ability to induce platelet activation and aggregation. This has been
documented to be involved in tumor progression in several types of cancers, such as lung …

Cathepsin K (CatK) is a part of the family of cysteine proteases involved in many important
processes, including the degradation activity of collagen 1 and elastin in bone resorption …

Although platelets are critically involved in thrombosis and hemostasis, experimental and
clinical evidence indicate that platelets promote tumor progression and metastasis through a …

Cancer patients experience a four-fold increase in thrombosis risk, indicating that cancer
development and progression are associated with platelet activation. Xenograft experiments …

Breast cancer is regarded worldwide as a severe human disease. Various genetic
variations, including hereditary and somatic mutations, contribute to the initiation and …

The establishment of prothrombotic states during cancer progression is well reported but the
precise mechanisms underlying this process remain elusive. A number of studies have …