Levetiracetam mechanisms of action: from molecules to systems

IJ Contreras-García, N Cárdenas-Rodríguez… - Pharmaceuticals, 2022 - mdpi.com
Epilepsy is a chronic disease that affects millions of people worldwide. Antiepileptic drugs
(AEDs) are used to control seizures. Even though parts of their mechanisms of action are …

Shared etiology in autism spectrum disorder and epilepsy with functional disability

A Zahra, YF Wang, Q Wang, J Wu - Behavioural Neurology, 2022 - Wiley Online Library
Autism spectrum disorders and epilepsies are heterogeneous human disorders that have
miscellaneous etiologies and pathophysiology. There is considerable risk of frequent …

Antiepileptogenic effects of trilostane in the kainic acid model of temporal lobe epilepsy

AM Costa, M Gol, C Lucchi, G Biagini - Epilepsia, 2023 - Wiley Online Library
Objective Epileptogenesis after status epilepticus (SE) has a faster onset in rats treated to
reduce brain levels of the anticonvulsant neurosteroid allopregnanolone with the 5α …

Antiseizure effects of cannabidiol leading to increased peroxisome proliferator-activated receptor gamma levels in the hippocampal CA3 subfield of epileptic rats

AM Costa, F Russo, L Senn, D Ibatici, G Cannazza… - Pharmaceuticals, 2022 - mdpi.com
We evaluated the effects of cannabidiol (CBD) on seizures and peroxisome proliferator-
activated receptor gamma (PPARγ) levels in an animal model of temporal lobe epilepsy …

The anti-seizure effect of liraglutide on Ptz-induced convulsions through its anti-oxidant and anti-inflammatory properties

MA Erdogan, A Erdogan, O Erbas - Neurochemical Research, 2023 - Springer
Epilepsy is a prevalent and frequently devastating neurological disorder defined by
recurring spontaneous seizures caused by aberrant electrical activity in the brain. Over ten …

Evaluation of e-health applications for paediatric patients with refractory epilepsy and maintained on ketogenic diet

AM Costa, M Marchiò, G Bruni, SM Bernabei… - Nutrients, 2021 - mdpi.com
E-health technologies improve healthcare quality and disease management. The aim of this
study was to develop a ketogenic diet management app as well as a website about this …

Functional connectivity discriminates epileptogenic states and predicts surgical outcome in children with drug resistant epilepsy

S Rijal, L Corona, MS Perry, E Tamilia, JR Madsen… - Scientific Reports, 2023 - nature.com
Normal brain functioning emerges from a complex interplay among regions forming
networks. In epilepsy, these networks are disrupted causing seizures. Highly connected …

Antiseizure Effects of Fully Characterized Non-Psychoactive Cannabis sativa L. Extracts in the Repeated 6-Hz Corneal Stimulation Test

AM Costa, L Senn, L Anceschi, V Brighenti, F Pellati… - Pharmaceuticals, 2021 - mdpi.com
Compounds present in Cannabis sativa L. preparations have recently attracted much
attention in the treatment of drug-resistant epilepsy. Here, we screened two olive oil extracts …

Anticonvulsant Activity of Hydro Alcoholic Extract and Solvent Fractions of Biophytum umbraculum Welw. Syn (Oxalidaceae) Root in Mice

N Fisseha, WW Hammeso, D Nureye - Journal of Experimental …, 2022 - Taylor & Francis
Background Scientists and researchers continue to focus on medicinal plants as a potential
source of lead chemicals in the search for and development of new antiepileptic medicines …

[HTML][HTML] Subthreshold cannabidiol potentiates levetiracetam in the kainic acid model of temporal lobe epilepsy: a pilot study

C Lucchi, M Marcucci, KAMS Aledresi, AM Costa… - Pharmaceuticals, 2024 - mdpi.com
Refractoriness to antiseizure medications is still a major concern in the pharmacotherapy of
epilepsy. For this reason, we decided to evaluate the combination of levetiracetam and …