Maintenance of endothelial cell integrity is an important component of human health and
disease since the endothelium can perform various functions including regulation of …

The endothelium plays important roles in modulating vascular tone by synthesizing and
releasing a variety of endothelium-derived relaxing factors, including vasodilator …

Prompted by the observation that atherosclerotic plaques from human diabetic subjects
displayed lower amounts of NADPH (nicotinamide adenine dinucleotide phosphate) …

Significance: Oxidative stress represents the common hallmark of pathological conditions
associated with cardiovascular disease (CVD), including atherosclerosis, heart failure …

Diabetic nephropathy (DN) is currently the leading cause of end-stage renal disease
globally. Given the increasing incidence of diabetes, many experts hold the view that DN will …

The age-related vasculature alteration is the prominent risk factor for vascular diseases
(VD), namely, atherosclerosis, abdominal aortic aneurysm, vascular calcification (VC) and …

Reactive oxygen species (ROS) affect many cellular functions and the proper redox balance
between ROS and antioxidants contributes substantially to the physiological welfare of the …

Diabetic nephropathy (DN) is a research priority for scientists around the world because of
its high prevalence and poor prognosis. Although several mechanisms have been shown to …

Diabetic nephropathy (DN) is one of the major microvascular complications of diabetes
mellitus and the leading cause of end-stage kidney disease. The standard treatments for …

Diabetic mellitus (DM) is a significant public health concern worldwide with an increased
incidence of morbidity and mortality, which is particularly due to the diabetic vascular …