Astrocyte glycogen and lactate: New insights into learning and memory mechanisms

CM Alberini, E Cruz, G Descalzi, B Bessières, V Gao - Glia, 2018 - Wiley Online Library
Memory, the ability to retain learned information, is necessary for survival. Thus far,
molecular and cellular investigations of memory formation and storage have mainly focused …

Is obesity an inflammatory condition?

UN Das - Nutrition, 2001 - Elsevier
Obesity may be a low-grade systemic inflammatory disease. Overweight and obese children
and adults have elevated serum levels of C-reactive protein, interleukin-6, tumor necrosis …

Lactate produced by glycogenolysis in astrocytes regulates memory processing

LA Newman, DL Korol, PE Gold - PloS one, 2011 - journals.plos.org
When administered either systemically or centrally, glucose is a potent enhancer of memory
processes. Measures of glucose levels in extracellular fluid in the rat hippocampus during …

The neurobiological basis of spontaneous alternation

R Lalonde - Neuroscience & Biobehavioral Reviews, 2002 - Elsevier
When placed in a T-maze, rats or mice possess a strong tendency of alternating arm choices
on successive trials. The exploration of novel environmental stimuli is dependent on the …

The value of spontaneous alternation behavior (SAB) as a test of retention in pharmacological investigations of memory

RN Hughes - Neuroscience & Biobehavioral Reviews, 2004 - Elsevier
Because of its reliance on memory, the tendency for rats, mice and other animals to alternate
successive choices of T-or Y-maze arms has assumed considerable popularity in …

The relationship between impaired glucose tolerance, type 2 diabetes, and cognitive function

N Awad, M Gagnon, C Messier - Journal of clinical and …, 2004 - Taylor & Francis
The present review integrates findings of published studies that have evaluated the
cognitive function of treated and untreated type 2 diabetic patients and provides a detailed …

The contribution of the medial prefrontal cortex, orbitofrontal cortex, and dorsomedial striatum to behavioral flexibility

ME Ragozzino - Annals of the New York academy of sciences, 2007 - Wiley Online Library
Behavioral flexibility refers to the ability to shift strategies or response patterns with a change
in environmental contingencies. The frontal lobe and basal ganglia are two brain regions …

Acetylcholine modulation of neural systems involved in learning and memory

PE Gold - Neurobiology of learning and memory, 2003 - Elsevier
Extensive evidence supports the view that cholinergic mechanisms modulate learning and
memory formation. This paper reviews evidence for cholinergic regulation of multiple …

NMDA receptor hypofunction produces concomitant firing rate potentiation and burst activity reduction in the prefrontal cortex

ME Jackson, H Homayoun… - Proceedings of the …, 2004 - National Acad Sciences
Cognitive deficits associated with frontal lobe dysfunction are a determinant of long-term
disability in schizophrenia and are not effectively treated with available medications. Clinical …

Cognitive demand and blood glucose

AB Scholey, S Harper, DO Kennedy - Physiology & behavior, 2001 - Elsevier
Previous research has identified that glucose administration can enhance cognitive
performance, especially during more intense cognitive processing. There appears to be a …