Myasthenia gravis is a relatively rare neurological disease that is associated with loss of the
acetylcholine receptors that initiate muscle contraction. This results in muscle weakness …

Much progress has been made in the 26 years since initial studies of the first purified
acetylcholine receptors (AChRs) led to the discovery that an antibody‐mediated …

We studied the cellular basis of self tolerance of B cells specific for brain autoantigens using
transgenic mice engineered to produce high titers of autoantibodies against the myelin …

We established six T cell clones specific for pyruvate dehydrogenase complex (PDC)-E2
peptides from four different patients with primary biliary cirrhosis using 33 different peptides …

Peptides that bind to major histocompatibility complex products (MHC) are known to exhibit
certain sequence motifs which, though common, are neither necessary nor sufficient for …

Studies of the structure and function of neuronal nicotinic acetylcholine receptors (AChRs)
evolved out of studies of muscle AChRs. This review will begin with a brief summary of …

Skeletal muscle can be both the site and target of immune reactions. Here, Reinhard
Hohlfeld and Andrew Engel consider the role of muscle as an immunological …

H uman autoimmune diseases have a striking genetic as-sociation with particular alleles of
major histocompatibility complex (MHC) class I or II genes. The field was established by the …

The nicotinic acetylcholine receptors (AChR) are presently the best-characterized
neurotransmitter receptors. They are pentamers of homologous or identical subunits …

Previous studies suggested that tetanus and diphtheria toxoids (TTD and DTD, respectively)
contain “universal” epitopes for human CD4+ cells (residues 632–651 and 950–969 of TTD …