Multicellular organisms are composed of diverse cell types that must coordinate their
behaviors through communication. Cell–cell communication (CCC) is essential for growth …

Mechanical properties play important roles at different scales in biology. At the level of a
single cell, the mechanical properties mediate mechanosensing and mechanotransduction …

Acting as a bridge between the cytoskeleton of the cell and the extra cellular matrix (ECM),
the cell-ECM adhesions with integrins at their core, play a major role in cell signalling to …

Actomyosin machinery endows cells with contractility at a single-cell level. However, within a
monolayer, cells can be contractile or extensile based on the direction of pushing or pulling …

Mechanosensing describes the ability of a cell to sense mechanical cues of its
microenvironment, including not only all components of force, stress, and strain but also …

There is growing appreciation of the importance of the mechanical properties of the tumor
microenvironment on disease progression. However, the role of extracellular matrix (ECM) …

The measurement of cellular traction forces on soft elastic substrates has become a
standard tool for many labs working on mechanobiology. Here we review the basic …

The filamentous actin (F-actin) cytoskeleton is a composite material consisting of cortical
actin and bundled F-actin stress fibers, which together mediate the mechanical behaviors of …

Polyacrylamide (PAM) hydrogels are commonly used as substrates for cell mechanical and
mechanobiological studies because of their tunable stiffness and ease of handling. The …

Defining the principles of T cell migration in structurally and mechanically complex tumor
microenvironments is critical to understanding escape from antitumor immunity and …