Oxidative stress and immune response in melanoma: ion channels as targets of therapy

A Remigante, S Spinelli, A Marino, M Pusch… - International Journal of …, 2023 - mdpi.com
Oxidative stress and immune response play an important role in the development of several
cancers, including melanoma. Ion channels are aberrantly expressed in tumour cells and …

Antioxidant Activity of Quercetin in a H2O2-Induced Oxidative Stress Model in Red Blood Cells: Functional Role of Band 3 Protein

A Remigante, S Spinelli, E Straface… - International journal of …, 2022 - mdpi.com
During their lifespan, red blood cells (RBCs) are exposed to a large number of stressors and
are therefore considered as a suitable model to investigate cell response to oxidative stress …

Recent advances in the structural biology of the volume-regulated anion channel LRRC8

G Kasuya, O Nureki - Frontiers in Pharmacology, 2022 - frontiersin.org
Members of the leucine-rich repeat-containing 8 (LRRC8) protein family, composed of five
LRRC8A-E isoforms, are pore-forming components of the volume-regulated anion channel …

Mechanisms underlying the anti-aging activity of bergamot (Citrus bergamia) extract in human red blood cells

A Remigante, S Spinelli, E Straface… - Frontiers in …, 2023 - frontiersin.org
Introduction: Aging is a process characterised by a decline in physiological functions.
Reactive species play a crucial role in the aging rate. Due to the close relationship between …

Cell volume controlled by LRRC8A-formed volume-regulated anion channels fine-tunes T cell activation and function

Y Wang, Z Sun, J Ping, J Tang, B He, T Chang… - Nature …, 2023 - nature.com
Biosynthesis drives the cell volume increase during T cell activation. However, the
contribution of cell volume regulation in TCR signaling during T lymphoblast formation and …

IK Channel-independent effects of clotrimazole and senicapoc on cancer cells viability and migration

P Zuccolini, R Barbieri, F Sbrana, C Picco… - International Journal of …, 2023 - mdpi.com
Many studies highlighted the importance of the IK channel for the proliferation and the
migration of different types of cancer cells, showing how IK blockers could slow down cancer …

Nicotinic Acid Adenine Dinucleotide Phosphate Induces Intracellular Ca2+ Signalling and Stimulates Proliferation in Human Cardiac Mesenchymal Stromal Cells

P Faris, C Casali, S Negri, L Iengo… - Frontiers in Cell and …, 2022 - frontiersin.org
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a newly discovered second
messenger that gates two pore channels 1 (TPC1) and 2 (TPC2) to elicit endo-lysosomal …

NS-11021 modulates cancer-associated processes independently of BK channels in melanoma and pancreatic duct adenocarcinoma cell lines

A Remigante, P Zuccolini, R Barbieri, L Ferrera… - Cancers, 2021 - mdpi.com
Simple Summary Potassium channels permit the selective passage of K+ ions across the
cell me brane and are important for setting the membrane potential and for the transmission …

Conditional deletion of LRRC8A in the brain reduces stroke damage independently of swelling-activated glutamate release

M Balkaya, P Dohare, S Chen, AL Schober, AM Fidaleo… - Iscience, 2023 - cell.com
The ubiquitous volume-regulated anion channels (VRACs) facilitate cell volume control and
contribute to many other physiological processes. Treatment with non-specific VRAC …

AAPH-induced oxidative damage reduced anion exchanger 1 (SLC4A1/AE1) activity in human red blood cells: protective effect of an anthocyanin-rich extract

A Remigante, S Spinelli, GT Patanè, D Barreca… - Frontiers in …, 2023 - frontiersin.org
Introduction: During their lifespan in the bloodstream, red blood cells (RBCs) are exposed to
multiple stressors, including increased oxidative stress, which can affect their morphology …