Sequestosome1 (p62/SQSTM 1) is a multidomain protein that interacts with the autophagy
machinery as a key adaptor of target cargo. It interacts with phagophores through the LC3 …

In the mammalian central nervous system, the majority of fast excitatory synaptic
transmission is mediated by glutamate acting on AMPA-type ionotropic glutamate receptors …

Many studies have reported the roles played by regulated proteolysis in synaptic plasticity
and memory, but the role of autophagy in neurons remains unclear. In mammalian cells …

Modulation of a specific prostanoid synthase or receptor provides therapeutic alternatives to
nonsteroidal anti-inflammatory drugs (NSAIDs) for treating pathological conditions governed …

p62 is a multidomain protein that contains different kinds of protein–protein interaction
domains, including an N-terminal PB1 domain, a ZZ-type zinc finger domain, a nuclear …

The p62/sequestosome-1 is a multifunctional protein containing several protein–protein
interaction domains. Through these interactions p62 is involved in the regulation of cellular …

Multiple aspects of neuronal physiology crucially depend on two cellular pathways,
autophagy and endocytosis. During endocytosis, extracellular components either unbound …

Abstract p62/SQSTM1 (hereafter as p62) is a stress-inducible cellular protein, which
interacts with various signaling proteins to regulate a variety of cellular functions. Growing …

Direct phosphorylation of GluA1 by PKC controls α‐amino‐3‐hydroxy‐5‐methyl‐isoxazole‐
4‐propionic acid (AMPA) receptor (AMPAR) incorporation into active synapses during long …

Amyotrophic Lateral Sclerosis (ALS) is an invariably fatal neurodegenerative disorder, which
specifically targets motor neurons in the brain, brain stem and spinal cord. Whilst the …