Bioluminescence is the fascinating natural phenomenon by which living creatures produce
light. Bioluminescence occurs when the oxidation of a small-molecule luciferin is catalysed …

Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …

The biomedical field has greatly benefited from the discovery of bioluminescent proteins.
Currently, scientists employ bioluminescent systems for numerous biomedical applications …

Molecular imaging is revolutionizing the way we study the inner workings of the human
body, diagnose diseases, approach drug design, and assess therapies. The field as a whole …

Despite the discovery of heterotrimeric αβγ G proteins∼ 25 years ago, their selective
perturbation by cell-permeable inhibitors remains a fundamental challenge. Here we report …

Luminescence imaging has gained attention as a promising bio-imaging modality in
situations where fluorescence imaging cannot be applied. However, wider application to …

Bacteria have long been the targets for genetic manipulation, but more recently they have
been synthetically designed to carry out specific tasks. Among the simplest of these tasks is …

Bioluminescence imaging (BLI) using luciferase reporters is an indispensable method for
the noninvasive visualization of cell populations and biochemical events in living animals …

High temporal and spatial regulation of cellular activities, biological pathways, and gene
expression is critical in complex biological processes.[1] One remarkable technique that …

Although fluorescent reporters and biosensors have become indispensable tools in
biological and biomedical fields, fluorescence measurements require external excitation …