The field of cAMP signaling is witnessing exciting developments with the recognition that
cAMP is compartmentalized and that spatial regulation of cAMP is critical for faithful signal …

The 5′-Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a natural
energy sensor in mammalian cells that plays a key role in cellular and systemic energy …

Adenylyl cyclases (ACs) catalyze the conversion of ATP to the ubiquitous second
messenger cAMP. Mammals possess nine isoforms of transmembrane ACs, dubbed AC1–9 …

The two branches of the autonomic nervous system (ANS), adrenergic and cholinergic, exert
a multitude of effects on the human myocardium thanks to the activation of distinct G protein …

Myocardial stress and injury invariably promote remodeling of the cardiac tissue, which is
associated with cardiomyocyte death and development of fibrosis. The fibrotic process is …

Cellular communications play pivotal roles in multi-cellular species, but they do so also in
uni-cellular species. Moreover, cells communicate with each other not only within the same …

Novel targeted fluorescent biosensors provide key insights into very local nanodomains of
cAMP and PKA activity, and how they respond differently to β-adrenergic activation in …

Under physiological conditions, cAMP signaling plays a key role in the regulation of cardiac
function. Activation of this intracellular signaling pathway mirrors cardiomyocyte adaptation …

Phosphodiesterases (PDEs) are the principal superfamily of enzymes responsible for
degrading the secondary messengers 3′, 5′-cyclic nucleotides cAMP and cGMP. Their …

Membrane adenylyl cyclases (ACs) catalyze the conversion of ATP to the ubiquitous second
messenger cAMP. As effector proteins of G protein-coupled receptors and other signaling …