Brain-derived neurotrophic factor in Alzheimer's disease and its pharmaceutical potential

L Gao, Y Zhang, K Sterling, W Song - Translational neurodegeneration, 2022 - Springer
Synaptic abnormalities are a cardinal feature of Alzheimer's disease (AD) that are known to
arise as the disease progresses. A growing body of evidence suggests that pathological …

Brain-derived neurotrophic factor in brain disorders: focus on neuroinflammation

B Lima Giacobbo, J Doorduin, HC Klein… - Molecular …, 2019 - Springer
Brain-derived neurotrophic factor (BDNF) is one of the most studied neurotrophins in the
healthy and diseased brain. As a result, there is a large body of evidence that associates …

[HTML][HTML] Physical exercise in the prevention and treatment of Alzheimer's disease

A De la Rosa, G Olaso-Gonzalez… - Journal of sport and …, 2020 - Elsevier
Dementia is one of the greatest global challenges for health and social care in the 21st
century. Alzheimer's disease (AD), the most common type of dementia, is by no means an …

[HTML][HTML] Brain-derived neurotrophic factor: a key molecule for memory in the healthy and the pathological brain

M Miranda, JF Morici, MB Zanoni… - Frontiers in cellular …, 2019 - frontiersin.org
Brain Derived Neurotrophic Factor (BDNF) is a key molecule involved in plastic changes
related to learning and memory. The expression of BDNF is highly regulated, and can lead …

Recent advances on the role of brain-derived neurotrophic factor (BDNF) in neurodegenerative diseases

KF Azman, R Zakaria - International journal of molecular sciences, 2022 - mdpi.com
Neurotrophins, such as brain-derived neurotrophic factor (BDNF), are essential for neuronal
survival and growth. The signaling cascades initiated by BDNF and its receptor are the key …

Decreased serum brain-derived neurotrophic factor (BDNF) levels in patients with Alzheimer's disease (AD): a systematic review and meta-analysis

TKS Ng, CSH Ho, WWS Tam, EH Kua… - International journal of …, 2019 - mdpi.com
Findings from previous studies reporting the levels of serum brain-derived neurotrophic
factor (BDNF) in patients with Alzheimer's disease (AD) and individuals with mild cognitive …

Brain-derived neurotrophic factor in mood disorders and antidepressant treatments

E Castrén, M Kojima - Neurobiology of disease, 2017 - Elsevier
Levels of brain-derived neurotrophic factor (BDNF) are reduced in the brain and serum of
depressed patients and at least the reduction in serum levels is reversible upon successful …

Brain-derived neurotropic factor in neurodegenerative disorders

AM Ibrahim, L Chauhan, A Bhardwaj, A Sharma… - Biomedicines, 2022 - mdpi.com
Globally, neurodegenerative diseases cause a significant degree of disability and distress.
Brain-derived neurotrophic factor (BDNF), primarily found in the brain, has a substantial role …

Neurotrophin signalling: novel insights into mechanisms and pathophysiology

M Mitre, A Mariga, MV Chao - Clinical science, 2017 - portlandpress.com
Neurotrophins, such as brain-derived neurotrophic factor (BDNF), are prominent regulators
of neuronal survival, growth and differentiation during development. While trophic factors are …

Lactate and BDNF: key mediators of exercise induced neuroplasticity?

P Müller, Y Duderstadt, V Lessmann… - Journal of Clinical …, 2020 - mdpi.com
Accumulating evidence from animal and human studies supports the notion that physical
exercise can enhance neuroplasticity and thus reduce the risk of several neurodegenerative …