Brain‐derived neurotrophic factor (BDNF) is a member of the neurotrophin family that plays
a critical role in numerous neuronal activities. Recent studies have indicated that some …

Neonatal hypoxia‐ischemia (HI) is an important cause of neurological deficits in humans,
and the Levine‐Rice model of experimental HI in the rat mimics the human brain lesion and …

Mitochondria are dynamic organelles responsible for cellular energy production. Besides,
regulating energy homeostasis, mitochondria are responsible for calcium homeostasis …

7, 8-dihydroxyflavone (7, 8-DHF), a newly identified small molecular TrkB receptor agonist,
rapidly activates TrkB in both primary neurons and the rodent brain and mimics the …

Uncontrolled oxidative stress contributes to the secondary neuronal death that promotes
long-term neurological dysfunction following traumatic brain injury (TBI). Surprisingly, both …

Flavonoids have long been known to exert benefits in various health problems. Among
them, the BDNF mimetic 7, 8-Dihydroxyflavone (7, 8-DHF) is emerging as a potential …

Huntington's disease (HD) is a fatal neurodegenerative disease with motor, cognitive and
psychiatric impairment. Dysfunctions in HD models have been related to reduced levels of …

Chronic activation of brain-derived neurotrophic factor (BDNF) receptor TrkB is a potential
method to prevent development of obesity, but the short half-life and nonbioavailable nature …

Brain-derived neurotrophic factor (BDNF)/tropomyosin-related kinase B (TrkB) pathway is
associated with ischemic heart diseases (IHD). 7, 8-dihydroxyflavone (7, 8-DHF), BDNF …

White matter injury is an important component of stroke pathology, but its pathophysiology
and potential treatment remain relatively elusive and underexplored. We previously reported …