The aims of severe perioperative bleeding management are three-fold. First, preoperative
identification by anamesis and laboratory testing of those patients for whom the …

Fibrinogen plays a critical role in achieving and maintaining hemostasis and is fundamental
to effective clot formation. There is increasing awareness of the important role of fibrinogen …

BACKGROUND: To explore whether disturbed fibrin polymerization is the main problem
underlying dilutional coagulopathy and can be reversed by fibrinogen administration, we …

Background: Infusion of artificial colloids such as hydroxyethyl starch (HES) induces
coagulopathy to a greater extent than simple dilution. Several studies have suggested that …

Background Hypofibrinogenaemia is associated with increased morbidity and mortality, but
the optimal treatment level, the use of preemptive treatment and the preferred source of …

Postinjury fibrinolysis can manifest as three distinguishable phenotypes: 1) hyperfibrinolysis,
2) physiologic, and 3) hypofibrinolysis (shutdown). Hyperfibrinolysis is associated with …

Background: The biochemical mechanisms causing dilutional coagulopathy following
infusion of hydroxyethyl starch 130/0.4 (HES) are not known in detail. Objectives: To give a …

Haemorrhage remains a major cause of potentially preventable deaths. Trauma and
massive transfusion are associated with coagulopathy secondary to tissue injury …

Fibrinogen is crucial for the formation of blood clot and clinical outcomes in major bleeding.
Both Thromboelastography (TEG) and Rotational Thromboelastometry (ROTEM) have been …

Purpose The management of trauma patients suffering from active bleeding has improved
with a better understanding of trauma-induced coagulopathy. The aim of this manuscript is to …