Mental illness modeling is still a major challenge for scientists. Animal models of
schizophrenia are essential to gain a better understanding of the disease etiopathology and …

Abstract 22q11. 2 deletion syndrome (22q11DS) is a highly penetrant and common genetic
cause of neuropsychiatric disease. Here we generated induced pluripotent stem cells from …

One of the most profound advances in the last decade of biomedical research has been the
development of human induced pluripotent stem cell (hiPSC) models for identification of …

Advances in 3D neuronal cultures, such as brain spheroids and organoids, are allowing
unprecedented in vitro access to some of the molecular, cellular and developmental …

Probing naturally-occurring, reciprocal genomic copy number variations (CNVs) may help us
understand mechanisms that underlie deviations from typical brain development. Cross …

Abstract Background 22q11. 2 copy number variants are among the most highly penetrant
genetic risk variants for developmental neuropsychiatric disorders such as schizophrenia …

The KCNT1 gene encodes the sodium-activated potassium channel Slack (KCNT1, K Na
1.1), a regulator of neuronal excitability. Gain-of-function mutations in humans cause cortical …

Background Chronic stress exposure increases the risk of mental health problems such as
anxiety and depression. The medial prefrontal cortex (mPFC) is a hub for controlling stress …

Genetic risk for psychiatric illness is complex, so identification of shared molecular pathways
where distinct forms of genetic risk might coincide is of substantial interest. A growing body …

Recent progress in human genetics and single cell sequencing rapidly expands the list of
molecular factors that offer important new contributions to our understanding of brain wiring …