Within the biomedical and pharmaceutical communities there is an ongoing need to find
new technologies that can be used to elucidate disease mechanisms and provide novel …

The development of RNA-encoded regulatory circuits relying on RNA-binding proteins
(RBPs) has enhanced the applicability and prospects of post-transcriptional synthetic …

Understanding and reshaping cellular behaviors with synthetic gene networks requires the
ability to sense and respond to changes in the intracellular environment. Intracellular …

Critical for diverse biological processes, proteases represent one of the largest families of
pharmaceutical targets. To inhibit pathogenic proteases with desired selectivity, monoclonal …

The robustness of complex biological processes in the face of environmental and genetic
perturbations is a key biological trait. However, while robustness has been extensively …

BACKGROUND & AIMS: Expression of the nonstructural protein (NS) 3/4A protease in cells
infected with hepatitis C virus (HCV) results in cleavage of the mitochondrial antiviral …

Hepatitis C virus (HCV) infection is a major cause of chronic liver disease and has become a
global health threat. No HCV vaccine is currently available and treatment with antiviral …

γ-Secretase is a membrane protein complex that catalyzes intramembrane proteolysis of a
variety of substrates including the amyloid β precursor protein of Alzheimer disease …

BACKGROUND/AIMS: Hepatitis C virus infection is a major worldwide health problem,
causing chronic hepatitis, cirrhosis and primary liver cancer. In addition to its role in the viral …

Hepatitis C virus (HCV) infection is a common cause of chronic liver disease and a serious
threat to human health. The HCV NS3/4A serine protease is necessary for viral replication …