Gene therapy is on its way to revolutionize the treatment of both inherited and acquired
diseases, by transferring nucleic acids to correct a disease-causing gene in the target cells …

Simple Summary The overall survival of brain cancer patients remains grim, with
conventional therapies such as chemotherapy and radiotherapy only providing marginal …

The selective degradation of disease-associated microRNA is promising for the
development of new therapeutic approaches. In this study, we engineered a series of bulge …

RNA-targeting therapeutics require highly efficient sequence-specific devices capable of
RNA irreversible degradation in vivo. The most developed methods of sequence-specific …

Chronic kidney disease (CKD) is a global public health issue that places an increasing
burden on the healthcare systems of both the developed and developing countries. CKD is a …