Disease and accompanying inflammation are uncommon outcomes of viral infection in
humans. Clinical inflammation occurs if steady-state cell-intrinsic and leukocytic immunity to …

The skin is a complex and dynamic ecosystem that is inhabited by many microorganisms.
Recent evidence highlights the profound reliance of the skin immune system on its resident …

Migration of leukocytes is essential for the induction, maintenance, and regulation of
immune responses. On their trafficking routes, leukocytes encounter microenvironments of …

Heterozygosity for human signal transducer and activator of transcription 3 (STAT3)
dominant-negative (DN) mutations underlies an autosomal dominant form of hyper …

Ras homology (RHO) GTPases are signalling proteins that have crucial roles in triggering
multiple immune functions. Through their interactions with a broad range of effectors and …

Abstract Dedicator of cytokinesis 8 (DOCK8) deficiency is a combined immunodeficiency
that exemplifies the broad clinical features of primary immunodeficiencies (PIDs), extending …

A growing number of monogenic immune-mediated diseases have been related to genes
involved in pathways of actin cytoskeleton remodeling. Increasing evidences associate …

Infection or inflammation of the skin recruits effector CD8+ T cells that enter the epidermis
and form populations of long-lived tissue-resident memory T (T RM) cells. These skin T RM …

Human microbiome studies have revealed the intricate interplay of host immunity and
bacterial communities to achieve homeostatic balance. Healthy skin microbial communities …

Dedicator of cytokinesis (DOCK) proteins constitute a family of evolutionarily conserved
guanine nucleotide exchange factors (GEFs) for the Rho family of GTPases. Although DOCK …