Survivin, a homodimeric protein and a member of the IAP family, plays a vital function in cell
survival and cycle progression by interacting with various proteins and complexes. Its …

The discovery of new therapeutic drugs is heavily reliant on the structural diversity and
pharmacological properties of heterocyclic compounds. Pyridine heterocyclic‐related …

Although a plethora of targeted anticancer small molecule drugs became available, the low
response rate and drug resistance imply the continuous need for expanding the anticancer …

The present study describes synthesizing a novel series of polyfunctionalized pyridine
congeners 1–18 and assessed for cytotoxic efficacies versus HCT-116, MCF-7, and HepG-2 …

Abstract New 5‐cyano‐6‐oxo‐pyridine‐based sulfonamides (6a–m and 8a–d) were
designed and synthesized to potentially inhibit both the epidermal growth factor receptor …

Based on studies that have reported the association between cancer and cardiovascular
diseases, new series of pyridine-(3a–o) and/or chromene-(4a–e) carbonitrile analogous …

Roburic acid (ROB) is a naturally occurred tetracyclic triterpenoid, and the anticancer activity
of this compound has not been reported. Docetaxel (DOC) is the first-line chemotherapeutic …

Pyridines have occupied a unique place in medicinal chemistry as it is widely profound as
natural products and formed the integral backbone of great number of drugs in the market. In …

Heterocyclic systems, which are essential in medicinal chemistry due to their promising
cytotoxic activity, are one of the most important families of organic molecules found in nature …

Background: The continuous need for new anticancer drugs is never-ending task due to
cancer resistance to the existing drugs. Objective: This article aimed to design, synthesis …