Iron is an essential trace element for multicellular organisms and nearly all microorganisms.
Although iron is abundant in the environment, common forms of iron are minimally soluble …

The iron hormone hepcidin and its receptor and cellular iron exporter ferroportin control the
major fluxes of iron into blood plasma: intestinal iron absorption, the delivery of recycled iron …

Disruptions in iron homeostasis from both iron deficiency and overload account for some of
the most common human diseases. Iron metabolism is balanced by two regulatory systems …

Iron lies at the center of a battle for nutritional resource between higher organisms and their
microbial pathogens. The iron status of the human host affects the pathogenicity of …

Iron is an essential but potentially hazardous biometal. Mammalian cells require sufficient
amounts of iron to satisfy metabolic needs or to accomplish specialized functions. Iron is …

BACKGROUND: Iron is utilized by several proteins as cofactor for major biological
processes. However, iron may also harm cells by catalyzing the generation of free radicals …

Impaired iron homeostasis and the suppressive effects of proinflammatory cytokines on
erythropoiesis, together with alterations of the erythrocyte membrane that impair its survival …

Iron and its homeostasis are intimately tied to the inflammatory response. The adaptation to
iron deficiency, which confers resistance to infection and improves the inflammatory …

BACKGROUND The peptide hormone hepcidin plays a central role in regulating dietary iron
absorption and body iron distribution. Many human diseases are associated with alterations …

Anemia is prevalent in patients with chronic kidney disease (CKD) and is associated with
lower quality of life and higher risk of adverse outcomes, including cardiovascular disease …