Natural macromolecules, such as proteins and nucleic acids, display various complex
functionalities in biological systems. These functionalities depend on the macromolecular …

A “foldamer” is an artificial oligomeric molecule with a regular secondary or tertiary structure
consisting of various building blocks. A “stapled peptide” is a peptide with stabilized …

Enzymes are predominantly proteins able to effectively and selectively catalyze highly
complex biochemical reactions in mild reaction conditions. Nevertheless, they are limited to …

Peptides and proteins attract enormous attention in many fields of academia and industry.
The introduction of unusual amino acids such as α, α-disubstituted α-amino acids or N-alkyl …

N‐terminal thiourea‐modified l‐Leu‐based peptide {(3, 5‐diCF3Ph) NHC (= S)‐(l‐Leu‐l‐
Leu‐Ac5c) 2‐OMe} with five‐membered ring α, α‐disubstituted α‐amino acids (Ac5c) …

We present an E-selective ring-closing metathesis reaction in α-helical stapled peptides at
positions i and i+ 4. The use of two chiral carbocyclic α, α-disubstituted α-amino acids,(1 S, 3 …

Benzo [X] quinoline (X= g or f: BQX) derivatives bearing bis-trifluoromethyl and amine
groups have been designed as push–pull-type fluorescent dyes. Through the synthesis of …

A chiral cyclic α, α-disubstituted α-amino acid,(S)-(−)-cucurbitine, which has a pyrrolidine
ring with a chiral center at the α-position, was synthesized, and its homopeptides were …

Micellar systems have been recognized as effective nanoreactors for performing chemical
reactions in aqueous solutions. This research aims to develop nanoreactors from polymeric …

A combination of rare-earth metal amides RE [N (SiMe 3) 2] 3 and chiral phenoxy-
functionalized amino alcohol proligands was developed to realize the enantioselective …