Emerging role of glutamate in the pathophysiology of major depressive disorder
K Hashimoto - Brain research reviews, 2009 - Elsevier
Major depressive disorder (MDD) is a common, chronic, recurrent mental illness that affects
millions of individuals worldwide. To date, the monoaminergic systems (serotonin …
millions of individuals worldwide. To date, the monoaminergic systems (serotonin …
Beyond monoamines: glutamatergic function in mood disorders
A Kugaya, G Sanacora - CNS spectrums, 2005 - cambridge.org
The monoamine theory has implicated abnormalities in serotonin and norepinephrine in the
pathophysiology of major depression and bipolar illness and contributed greatly to our …
pathophysiology of major depression and bipolar illness and contributed greatly to our …
Role of calcium, glutamate and NMDA in major depression and therapeutic application
L Deutschenbaur, J Beck, A Kiyhankhadiv… - Progress in Neuro …, 2016 - Elsevier
Major depression is a common, recurrent mental illness that affects millions of people
worldwide. Recently, a unique fast neuroprotective and antidepressant treatment effect has …
worldwide. Recently, a unique fast neuroprotective and antidepressant treatment effect has …
Glutamatergic modulators: the future of treating mood disorders?
Mood disorders such as bipolar disorder and major depressive disorder are common,
chronic, and recurrent conditions affecting millions of individuals worldwide. Existing …
chronic, and recurrent conditions affecting millions of individuals worldwide. Existing …
Metabotropic glutamate receptor ligands as possible anxiolytic and antidepressant drugs
Depression and anxiety represent a major problem. However, the current treatment of both
groups of diseases is not satisfactory. As the glutamatergic system may play an important …
groups of diseases is not satisfactory. As the glutamatergic system may play an important …
Targeting metabotropic glutamate receptors for the treatment of depression and other stress-related disorders
The discovery of robust antidepressant effects of ketamine in refractory patients has led to
increasing focus on agents targeting glutamatergic signaling as potential novel …
increasing focus on agents targeting glutamatergic signaling as potential novel …
The role of glutamate on the action of antidepressants
K Hashimoto - Progress in Neuro-Psychopharmacology and …, 2011 - Elsevier
Major depressive disorder (MDD) is a common, chronic, recurrent mental illness that affects
millions of individuals worldwide. Currently available antidepressants are known to affect the …
millions of individuals worldwide. Currently available antidepressants are known to affect the …
Antidepressant-like effects of mGluR1 and mGluR5 antagonists in the rat forced swim and the mouse tail suspension tests
Drugs that act to reduce glutamatergic neurotransmission such as NMDA receptor
antagonists exert antidepressant-like effects in a variety of experimental paradigms, but their …
antagonists exert antidepressant-like effects in a variety of experimental paradigms, but their …
The role of the tripartite glutamatergic synapse in the pathophysiology and therapeutics of mood disorders
R Machado-Vieira, HK Manji… - The Neuroscientist, 2009 - journals.sagepub.com
Bipolar disorder and major depressive disorder are common, chronic, and recurrent mood
disorders that affect the lives of millions of individuals worldwide. Growing evidence …
disorders that affect the lives of millions of individuals worldwide. Growing evidence …
[HTML][HTML] The role of glutamatergic neurotransmission in the motor and non-motor symptoms in Parkinson's disease: clinical cases and a review of the literature
J Pagonabarraga, M Tinazzi, C Caccia… - Journal of Clinical …, 2021 - Elsevier
Glutamate is the major excitatory neurotransmitter in the central nervous system and, as
such, many brain regions, including the basal ganglia, are rich in glutamatergic neurons …
such, many brain regions, including the basal ganglia, are rich in glutamatergic neurons …