Microglial cells: the main HIV-1 reservoir in the brain
C Wallet, M De Rovere, J Van Assche… - Frontiers in cellular …, 2019 - frontiersin.org
Despite efficient combination of the antiretroviral therapy (cART), which significantly
decreased mortality and morbidity of HIV-1 infection, a definitive HIV cure has not been …
decreased mortality and morbidity of HIV-1 infection, a definitive HIV cure has not been …
The current status of latency reversing agents for HIV-1 remission
A Rodari, G Darcis, CM Van Lint - Annual review of virology, 2021 - annualreviews.org
Combinatory antiretroviral therapy (cART) reduces human immunodeficiency virus type 1
(HIV-1) replication but is not curative because cART interruption almost invariably leads to a …
(HIV-1) replication but is not curative because cART interruption almost invariably leads to a …
HIV “shock and kill” therapy: In need of revision
The implementation of antiretroviral therapy 23 years ago has rendered HIV infection
clinically manageable. However, the disease remains incurable, since it establishes latent …
clinically manageable. However, the disease remains incurable, since it establishes latent …
An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B …
The persistence of latently infected cells in patients under combinatory antiretroviral therapy
(cART) is a major hurdle to HIV-1 eradication. Strategies to purge these reservoirs are …
(cART) is a major hurdle to HIV-1 eradication. Strategies to purge these reservoirs are …
Latency reversal agents affect differently the latent reservoir present in distinct CD4+ T subpopulations
J Grau-Expósito, L Luque-Ballesteros, J Navarro… - PLoS …, 2019 - journals.plos.org
Latency reversal agents (LRAs) have proven to induce HIV-1 transcription in vivo but are
ineffective at decreasing the size of the latent reservoir in antiretroviral treated patients. The …
ineffective at decreasing the size of the latent reservoir in antiretroviral treated patients. The …
Novel latency reversal agents for HIV-1 cure
AM Spivak, V Planelles - Annual review of medicine, 2018 - annualreviews.org
Antiretroviral therapy (ART) has rendered HIV-1 infection a treatable illness; however, ART
is not curative owing to the persistence of replication-competent, latent proviruses in long …
is not curative owing to the persistence of replication-competent, latent proviruses in long …
HIV latency: should we shock or lock?
G Darcis, B Van Driessche, C Van Lint - Trends in immunology, 2017 - cell.com
Combinatory antiretroviral therapy (cART) increases the survival and quality of life of HIV-1-
infected patients. However, interruption of therapy almost invariably leads to the re …
infected patients. However, interruption of therapy almost invariably leads to the re …
Synergistic reactivation of latent HIV expression by ingenol-3-angelate, PEP005, targeted NF-kB signaling in combination with JQ1 induced p-TEFb activation
Although anti-retroviral therapy (ART) is highly effective in suppressing HIV replication, it
fails to eradicate the virus from HIV-infected individuals. Stable latent HIV reservoirs are …
fails to eradicate the virus from HIV-infected individuals. Stable latent HIV reservoirs are …
HIV latency is reversed by ACSS2-driven histone crotonylation
Eradication of HIV-1 (HIV) is hindered by stable viral reservoirs. Viral latency is
epigenetically regulated. While the effects of histone acetylation and methylation at the HIV …
epigenetically regulated. While the effects of histone acetylation and methylation at the HIV …
Reactivation of simian immunodeficiency virus reservoirs in the brain of virally suppressed macaques
Objective: Resting CD4+ T cells have been recognized as the major cell reservoir of latent
HIV-1 during antiretroviral therapy (ART). Using an simian immunodeficiency virus …
HIV-1 during antiretroviral therapy (ART). Using an simian immunodeficiency virus …