Nociceptor inputs can trigger a prolonged but reversible increase in the excitability and
synaptic efficacy of neurons in central nociceptive pathways, the phenomenon of central …

The highly disagreeable sensation of pain results from an extraordinarily complex and
interactive series of mechanisms integrated at all levels of the neuroaxis, from the periphery …

Repetitive stimulation of small diameter primary afferent fibres produces a progressive
increase in action potential discharge (windup) and a prolonged increase in the excitability …

Synaptic plasticity is fundamental to many neurobiological functions, including memory and
pain. Central sensitization refers to the increased synaptic efficacy established in …

In this study, we developed a rat model of incisional pain. A 1-cm longitudinal incision was
made through skin, fascia and muscle of the plantar aspect of the hindpaw in halothane …

Peripheral tissue damage or nerve injury often leads to pathological pain processes, such
as spontaneous pain, hyperalgesia and allodynia, that persist for years or decades after all …

Modern pain-control theory predicts that a loss of inhibition (disinhibition) in the dorsal horn
of the spinal cord is a crucial substrate for chronic pain syndromes. However, the nature of …

Phantom-limb pain is a common sequela of amputation, occurring in up to 80% of people
who undergo the procedure. It must be differentiated from non-painful phantom phenomena …

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Background context: Despite clinical evidence for the benefits of spinal maniputation and the
apparent wide usage of it, the biological mechanisms underlying the effects of spinal …