iPSCs and DRGs: stepping stones to new pain therapies

M Alsaloum, SG Waxman - Trends in molecular medicine, 2022 - cell.com
There is a pressing need for more effective nonaddictive treatment options for pain. Pain
signals are transmitted from the periphery into the spinal cord via dorsal root ganglion (DRG) …

Voltage-Gated Na+ Channels in Alzheimer's Disease: Physiological Roles and Therapeutic Potential

TJ Baumgartner, Z Haghighijoo, NA Goode, NM Dvorak… - Life, 2023 - mdpi.com
Alzheimer's disease (AD) is the most common cause of dementia and is classically
characterized by two major histopathological abnormalities: extracellular plaques composed …

LRRC37B is a human modifier of voltage-gated sodium channels and axon excitability in cortical neurons

B Libé-Philippot, A Lejeune, K Wierda, N Louros… - Cell, 2023 - cell.com
The enhanced cognitive abilities characterizing the human species result from specialized
features of neurons and circuits. Here, we report that the hominid-specific gene LRRC37B …

FGF homologous factors are secreted from cells to induce FGFR‐mediated anti‐apoptotic response

M Biadun, M Sochacka, R Karelus, K Baran… - The FASEB …, 2023 - Wiley Online Library
FGF homologous factors (FHFs) are the least described group of fibroblast growth factors
(FGFs). The FHF subfamily consists of four proteins: FGF11, FGF12, FGF13, and FGF14 …

FHF1 is a bona fide fibroblast growth factor that activates cellular signaling in FGFR-dependent manner

M Sochacka, L Opalinski, J Szymczyk… - Cell Communication and …, 2020 - Springer
Fibroblast growth factors (FGFs) via their receptors (FGFRs) transduce signals from the
extracellular space to the cell interior, modulating pivotal cellular processes such as cell …

Determinants of iFGF13-mediated regulation of myocardial voltage-gated sodium (NaV) channels in mouse

A Lesage, M Lorenzini, S Burel, M Sarlandie… - Journal of General …, 2023 - rupress.org
Posttranslational regulation of cardiac NaV1. 5 channels is critical in modulating channel
expression and function, yet their regulation by phosphorylation of accessory proteins has …

Hemokinin-1 gene expression is upregulated in trigeminal ganglia in an inflammatory orofacial pain model: potential role in peripheral sensitization

T Aczél, A Kecskés, J Kun, K Szenthe, F Bánáti… - International journal of …, 2020 - mdpi.com
A large percentage of primary sensory neurons in the trigeminal ganglia (TG) contain
neuropeptides such as tachykinins or calcitonin gene-related peptide. Neuropeptides …

[HTML][HTML] FGF12 regulates cell cycle gene expression and promotes follicular granulosa cell proliferation through ERK phosphorylation in geese

W Yang, S Yu, J Peng, P Chang, X Chen - Poultry Science, 2023 - Elsevier
The granulosa cells play an important role in the fate of follicular development or atresia in
poultry. Fibroblast growth factor 12 (FGF12) is downregulated in atretic follicles and may be …

Differential Modulation of the Voltage-Gated Na+ Channel 1.6 by Peptides Derived From Fibroblast Growth Factor 14

AK Singh, NM Dvorak, CM Tapia… - Frontiers in Molecular …, 2021 - frontiersin.org
The voltage-gated Na+ (Nav) channel is a primary molecular determinant of the initiation
and propagation of the action potential. Despite the central role of the pore-forming α subunit …

Fibroblast growth factor homologous factor 2 attenuates excitability of DRG neurons

PR Effraim, M Estacion, P Zhao… - Journal of …, 2022 - journals.physiology.org
Fibroblast growth factor homologous factors (FHFs) are cytosolic members of the
superfamily of the FGF proteins. Four members of this subfamily (FHF1–4) are differentially …