The spinocerebellar ataxias (SCAs) comprise more than 40 autosomal dominant
neurodegenerative disorders that present principally with progressive ataxia. Within the past …

Synaptic plasticity (eg, long-term potentiation [LTP]) is considered the cellular correlate of
learning. Recent optogenetic studies on memory engram formation assign a critical role in …

This article highlights specific features of biological neurons and their dendritic trees, whose
adoption may help advance artificial neural networks used in various machine learning …

Canonically, each Purkinje cell (PC) in the adult cerebellum receives only one climbing fiber
(CF) from the inferior olive. Underlying current theories of cerebellar function is the notion …

Cerebellar dysfunction relates to various psychiatric disorders, including autism spectrum
and depressive disorders. However, the physiological aspect is less advanced. Here, we …

The cerebellum is emerging as a powerful regulator of cognitive and affective processing
and memory in both humans and animals and has been implicated in affective disorders …

A puzzling observation in the study of autism spectrum disorder (ASD) in mouse models has
been the deregulation of long-term synaptic depression (LTD), a form of experience …

Neurons store information by changing synaptic input weights. In addition, they can adjust
their membrane excitability to alter spike output. Here, we demonstrate a role of such …

Gated solely by activity-induced changes in intracellular calcium, small-conductance
potassium channels (SKs) are critical for a variety of functions in the CNS, from learning and …

Despite the canonical homogeneous character of its organization, the cerebellum plays
differential computational roles in distinct sensorimotor behaviors. Previously, we showed …