Adenosine triphosphate (ATP) has been well established as an important extracellular
ligand of autocrine signaling, intercellular communication, and neurotransmission with …

Endothelial cells (EC) form a unique signal-transducing surface in the vascular system. The
abundance of ion channels in the plasma membrane of these nonexcitable cells has raised …

Regulation of cell volume is critical for many cellular and organismal functions, yet the
molecular identity of a key player, the volume-regulated anion channel VRAC, has remained …

Cells need to regulate their volume to counteract osmotic swelling or shrinkage, as well as
during cell division, growth, migration and cell death. Mammalian cells adjust their volume …

The maintenance of a constant volume in the face of extracellular and intracellular osmotic
perturbation is essential for the normal function and survival of animal cells. Osmotically …

In recent years, it has become evident that the volume of a given cell is an important factor
not only in defining its intracellular osmolality and its shape, but also in defining other …

Various gating mechanisms of ion channels have been described, such as the shift of the $4
subunit of voltage-operated ion channels, the ball-and-chain mechanism of K+ and some …

▪ Abstract The functional impact of ion channels in vascular endothelial cells (ECs) is still a
matter of controversy. This review describes different types of ion channels in ECs and their …

Schultz, BD, AK Singh, DC Devor, and RJ Bridges. Pharmacology of CFTR Chloride
Channel Activity. Physiol. Rev. 79, Suppl.: S109–S144, 1999.—The pharmacology of cystic …

Change in the intracellular concentration of osmolytes or the extracellular tonicity results in a
rapid transmembrane water flow in mammalian cells until intracellular and extracellular …