Active targeting of gold nanoparticles as cancer therapeutics

ZR Goddard, MJ Marín, DA Russell… - Chemical Society …, 2020 - pubs.rsc.org
Gold nanoparticles (AuNPs) are of increasing interest for their unique properties and their
biocompatability, minimal toxicity, multivalency and size tunability make them exciting drug …

Diagnosis and detection of pancreatic cancer

LC Chu, MG Goggins, EK Fishman - The Cancer Journal, 2017 - journals.lww.com
Computed tomography is the first-line imaging modality for suspected pancreatic cancer.
Magnetic resonance cholangiopancreatography is a second-line modality for suspected …

Supramolecular nanofibrils formed by coassembly of clinically approved drugs for tumor photothermal immunotherapy

S Li, W Zhang, R Xing, C Yuan, H Xue… - Advanced …, 2021 - Wiley Online Library
Pancreatic cancer, one of the most lethal malignancies, compromises the performance of
traditional therapeutic regimens in the clinic because of stromal resistance to systemic drug …

Pancreatic cancer

J Kleeff, M Korc, M Apte, C La Vecchia… - Nature reviews Disease …, 2016 - nature.com
Pancreatic cancer is a major cause of cancer-associated mortality, with a dismal overall
prognosis that has remained virtually unchanged for many decades. Currently, prevention or …

The role of stroma in pancreatic cancer: diagnostic and therapeutic implications

M Erkan, S Hausmann, CW Michalski… - Nature reviews …, 2012 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is one of the five most lethal malignancies
worldwide and survival has not improved substantially in the past 30 years. Desmoplasia …

Tumor-targeting peptides from combinatorial libraries

R Liu, X Li, W Xiao, KS Lam - Advanced drug delivery reviews, 2017 - Elsevier
Cancer is one of the major and leading causes of death worldwide. Two of the greatest
challenges in fighting cancer are early detection and effective treatments with no or …

Combinatorial peptide libraries: mining for cell-binding peptides

BP Gray, KC Brown - Chemical reviews, 2014 - ACS Publications
The surface of a cell represents a collection of macromolecules, which provides the cell with
a unique cellular landscape specific to the type and state of the cell. Ligands that …

Mutant KRAS–induced expression of ICAM-1 in pancreatic acinar cells causes attraction of macrophages to expedite the formation of precancerous lesions

GY Liou, H Döppler, B Necela, B Edenfield, L Zhang… - Cancer discovery, 2015 - AACR
Desmoplasia and an inflammatory environment are defining features of pancreatic cancer.
Unclear is how pancreatic cells that undergo oncogenic transformation can cross-talk with …

The potential roles of exosomes in pancreatic cancer initiation and metastasis

W Sun, Y Ren, Z Lu, X Zhao - Molecular cancer, 2020 - Springer
Pancreatic cancer (PaCa) is an insidious and highly metastatic malignancy, with a 5-year
survival rate of less than 5%. So far, the pathogenesis and progression mechanisms of …

The impact of biomarkers in pancreatic ductal adenocarcinoma on diagnosis, surveillance and therapy

N Sturm, TJ Ettrich, L Perkhofer - Cancers, 2022 - mdpi.com
Simple Summary Pancreatic ductal adenocarcinoma is a leading cause of cancer death
worldwide. Due to the frequently late diagnosis, early metastasis and high therapy …