Approaches to characterize chromatin subcompartment organization in the cell nucleus
The mechanism of self-organization of chromatin subcompartments on the 0.1–1 μm scale
and their impact on genome-associated activities has long been a key aspect of research on …
and their impact on genome-associated activities has long been a key aspect of research on …
Revisiting the model for coactivator recruitment: Med15 can select its target sites independent of promoter-bound transcription factors
Activation domains (ADs) within transcription factors (TFs) induce gene expression by
recruiting coactivators such as the Mediator complex. Coactivators lack DNA binding …
recruiting coactivators such as the Mediator complex. Coactivators lack DNA binding …
Molecular determinants of condensate composition
AS Holehouse, S Alberti - Molecular Cell, 2025 - cell.com
Cells use membraneless compartments to organize their interiors, and recent research has
begun to uncover the molecular principles underlying their assembly. Here, we explore how …
begun to uncover the molecular principles underlying their assembly. Here, we explore how …
Sequence-and chemical specificity define the functional landscape of intrinsically disordered regions
I Langstein-Skora, A Schmid, F Huth, D Shabani… - BioRxiv, 2022 - biorxiv.org
Intrinsically disordered protein regions (IDRs) pervasively engage in essential molecular
functions, yet they are often poorly conserved as assessed by sequence alignment. To …
functions, yet they are often poorly conserved as assessed by sequence alignment. To …
Disordered sequences of transcription factors regulate genomic binding by integrating diverse sequence grammars and interaction types
Intrinsically disordered regions (IDRs) guide transcription factors (TFs) to their genomic
binding sites, raising the question of how structure-lacking regions encode for complex …
binding sites, raising the question of how structure-lacking regions encode for complex …
Intrinsically disordered regions of the Msn2 transcription factor encode multiple functions using interwoven sequence grammars
Intrinsically disordered regions (IDRs) are abundant in eukaryotic proteins, but their
sequence-function relationship remains poorly understood. IDRs of transcription factors …
sequence-function relationship remains poorly understood. IDRs of transcription factors …
Deciphering the dynamic code: DNA recognition by transcription factors in the ever-changing genome
Transcription factors (TFs) intricately navigate the vast genomic landscape to locate and
bind specific DNA sequences for the regulation of gene expression programs. These …
bind specific DNA sequences for the regulation of gene expression programs. These …
[HTML][HTML] Arid5a uses disordered extensions of its core ARID domain for distinct DNA-and RNA-recognition and gene regulation
J von Ehr, L Oberstrass, E Yazgan… - Journal of Biological …, 2024 - Elsevier
AT-rich interacting domain (ARID)-containing proteins, Arids, are a heterogeneous DNA-
binding protein family involved in transcription regulation and chromatin processing. For the …
binding protein family involved in transcription regulation and chromatin processing. For the …
Grammar rules and exceptions for the language of transcriptional activation domains
Transcriptional activation domains (ADs) of gene activators have remained enigmatic for
decades as short, extremely variable, and structurally disordered sequences. Using a …
decades as short, extremely variable, and structurally disordered sequences. Using a …
[PDF][PDF] Structural Biology
R Weinmann, L Frank, K Rippe - Current …, 2023 - malone.bioquant.uni-heidelberg.de
The mechanism of self-organization of chromatin subcompartments on the 0.1–1 μm scale
and their impact on genomeassociated activities has long been a key aspect of research on …
and their impact on genomeassociated activities has long been a key aspect of research on …