Cardiovascular disease is the major cause of mortality and disability, with hypertension
being the most prevalent risk factor. Excessive activation of the renin-angiotensin system …

RNA splicing has been recognized in recent years as a pivotal player in heart development
and disease. The Ca2+/calmodulin dependent protein kinase II delta (CaMKIIδ) is a …

Diminazene aceturate (DIZE), a putative angiotensin-converting enzyme 2 (ACE2) activator,
elicits relaxation in various animal models. This study aimed to determine the relaxing …

Cell membrane deformation is an important feature that occurs during many physiological
processes, and its study has been put to good use to investigate cardiomyocyte function …

The renin-angiotensin system (RAS) is a network of proteins regulating many aspects of
human physiology, including cardiovascular, pulmonary, and immune system physiology …

G protein-coupled receptors (GPCRs) have emerged as key players in regulating (patho)
physiological processes, including inflammation. Members of the Mas-related G protein …

BACKGROUND: Nitric oxide (NO) has been identified as a signaling molecule generated
during β-adrenergic receptor stimulation in the heart. Furthermore, a role for NO in triggering …

Objective Pressure overload can result in significant changes to the structure of blood
vessels, a process known as vascular remodeling. High levels of tension can cause vascular …

Cardiovascular diseases (CVDs) tend to affect the young population and are associated with
a significant economic burden and psychological distress to the society and families. The …

The cardiac circadian clock is responsible for the modulation of different myocardial
processes, and its dysregulation has been linked to disease development. How this clock …