Over the past decade, CRISPR has become as much a verb as it is an acronym,
transforming biomedical research and providing entirely new approaches for dissecting all …

The past 25 years of genomics research first revealed which genes are encoded by the
human genome and then a detailed catalogue of human genome variation associated with …

The discovery of the role of non-coding RNAs (ncRNAs) in the onset and progression of
malignancies is a promising frontier of cancer genetics. It is clear that ncRNAs are …

Acute myeloid leukemia (AML) is a deadly hematologic malignancy characterized by the
uncontrolled growth of immature myeloid cells. Over the past several decades, we have …

Cerebral infarction/ischemia-reperfusion injury is currently the disease with the highest
mortality and disability rate of cardiovascular disease. Current studies have shown that …

Inflammatory signaling underlies many diseases, from arthritis to cancer. Our understanding
of inflammation has thus far been limited to the world of proteins, because we are only just …

Simple Summary The cancer-immunity cycle is characterized by various stimulatory and
inhibitory factors, which together regulate the immune response and halt the extreme …

The steady progress in genome editing, especially genome editing based on the use of
clustered regularly interspaced short palindromic repeats (CRISPR) and programmable …

The underlying cause of cancer is genetic disruption, so gene editing technologies,
particularly CRISPR/Cas systems can be used to go against cancer. The field of gene …

Tumor associated macrophage responses are regulated by distinct metabolic states that
affect their function. However, the ability of specific signals in the local tumor …