Brain-derived neurotrophic factor (BDNF) is one of the most distributed and extensively
studied neurotrophins in the mammalian brain. BDNF signals through the tropomycin …

GABA is the major inhibitory neurotransmitter that counterbalances excitation in the mature
brain. The inhibitory action of GABA relies on the inflow of chloride ions (Cl−), which …

A single, low dose of the NMDA receptor antagonist ketamine produces rapid
antidepressant actions in treatment-resistant depressed patients. Understanding the cellular …

Since its discovery almost three decades ago, the secreted neurotrophin brain-derived
neurotrophic factor (BDNF) has been firmly implicated in the differentiation and survival of …

Interest in BDNF as an activity-dependent modulator of neuronal structure and function in
the adult brain has intensified in recent years. Localization of BDNF-TrkB to glutamate …

Brain-derived neurotrophic factor (BDNF) and other members of the protein family of
neurotrophins have been implicated in a multitude of processes that are important for …

Overwhelming evidence collected since the early 1990's strongly supports the notion that
BDNF is among the key regulators of synaptic plasticity in many areas of the mammalian …

In the past 15 years numerous reports provided strong evidence that brain-derived
neurotrophic factor (BDNF) is one of the most important modulators of glutamatergic and …

Brain-derived neurotrophic factor (BDNF) attracts increasing attention from both research
and clinical fields because of its important functions in the central nervous system. An …

Brain-derived nerve factor (BDNF), through TrkB receptor activation, is an important
modulator for many different physiological and pathological functions in the nervous system …