Challenges and developing solutions for increasing the benefits of IL-2 treatment in tumor therapy
D Skrombolas, JG Frelinger - Expert review of clinical immunology, 2014 - Taylor & Francis
Interleukin-2 (IL-2) is a cytokine with pleiotropic effects on the immune system. Systemic IL-2
treatment has produced durable responses in melanoma and renal cancer patients, but …
treatment has produced durable responses in melanoma and renal cancer patients, but …
Interleukin-2: old and new approaches to enhance immune-therapeutic efficacy
P Dhupkar, N Gordon - Immunotherapy, 2017 - Springer
Abstract Interleukin-2 (IL-2) is a very well-known cytokine that has been studied for the past
35 years. It plays a major role in the growth and proliferation of many immune cells such NK …
35 years. It plays a major role in the growth and proliferation of many immune cells such NK …
[HTML][HTML] Antibodies to interleukin-2 elicit selective T cell subset potentiation through distinct conformational mechanisms
Summary Interleukin-2 (IL-2) is a pleiotropic cytokine that regulates immune cell
homeostasis and has been used to treat a range of disorders including cancer and …
homeostasis and has been used to treat a range of disorders including cancer and …
Human IL-2 mutein with higher antitumor efficacy than wild type IL-2
T Carmenate, A Pacios, M Enamorado… - The Journal of …, 2013 - journals.aai.org
IL-2 has been used for the treatment of melanoma and renal cell carcinoma, but this therapy
has limited efficacy and severe toxicity. Currently, it is assumed that part of the limited …
has limited efficacy and severe toxicity. Currently, it is assumed that part of the limited …
Improved cancer immunotherapy by a CD25-mimobody conferring selectivity to human interleukin-2
N Arenas-Ramirez, C Zou, S Popp, D Zingg… - Science translational …, 2016 - science.org
Interleukin-2 (IL-2) immunotherapy is an attractive approach in treating advanced cancer.
However, by binding to its IL-2 receptor α (CD25) subunit, IL-2 exerts unwanted effects …
However, by binding to its IL-2 receptor α (CD25) subunit, IL-2 exerts unwanted effects …
Blocking IL-2 signal in vivo with an IL-2 antagonist reduces tumor growth through the control of regulatory T cells
T Carmenate, Y Ortíz, M Enamorado… - The Journal of …, 2018 - journals.aai.org
IL-2 is critical for peripheral tolerance mediated by regulatory T (Treg) cells, which represent
an obstacle for effective cancer immunotherapy. Although IL-2 is important for effector (E) T …
an obstacle for effective cancer immunotherapy. Although IL-2 is important for effector (E) T …
CD4+ T cells support polyfunctionality of cytotoxic CD8+ T cells with memory potential in immunological control of tumor
N Imai, I Tawara, M Yamane, D Muraoka… - Cancer …, 2020 - Wiley Online Library
Polyfunctionality/multifunctionality of effector T cells at the single cell level has been shown
as an important parameter to predict the quality of T cell response and immunological …
as an important parameter to predict the quality of T cell response and immunological …
IL-2/anti-IL-2 mAb immunocomplexes: A renascence of IL-2 in cancer immunotherapy?
J Tomala, M Kovar - Oncoimmunology, 2016 - Taylor & Francis
The in vivo biological activity of IL-2 can be dramatically increased by complexing with anti-
IL-2 mAb. Moreover, IL-2/anti-IL-2 mAb immunocomplexes selectively stimulate different …
IL-2 mAb. Moreover, IL-2/anti-IL-2 mAb immunocomplexes selectively stimulate different …
Affinity maturation and fine functional mapping of an antibody fragment against a novel neutralizing epitope on human vascular endothelial growth factor
H Lamdan, JV Gavilondo, Y Muñoz, A Pupo… - Molecular …, 2013 - pubs.rsc.org
We have previously reported the isolation of a novel single-chain variable fragment (scFv)
against vascular endothelial growth factor (VEGF), from a phage-displayed human antibody …
against vascular endothelial growth factor (VEGF), from a phage-displayed human antibody …
High throughput functional epitope mapping: revisiting phage display platform to scan target antigen surface
G Rojas, Y Tundidor, YC Infante - MAbs, 2014 - Taylor & Francis
Antibody engineering must be accompanied by mapping strategies focused on identifying
the epitope recognized by each antibody to define its unique functional identity. High …
the epitope recognized by each antibody to define its unique functional identity. High …