Nicotine is of importance as the addictive chemical in tobacco, pharmacotherapy for
smoking cessation, a potential medication for several diseases, and a useful probe drug for …

This review examines the involvement of cytochrome P450 (CYP) enzymes in the formation
of reactive oxygen species in biological systems and discusses the possible involvement of …

Abstract The cytochrome P450 (P450) enzymes first attracted interest because of their
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …

Much of P450 research has always been done with the view of appUcation to humans, even
when done with experimental animals and microorganisms. Research with the human …

The concept of overexpression of individual forms of cytochrome P 450 enzymes in tumor
cells is now becoming well recognized. Indeed, a growing body of research highlights the …

Background: Cancer cells use several mechanisms to resist the cytotoxic effects of drugs,
resulting in tumor progression and invasion. One such mechanism capitalizes on the body's …

Disinfection of water system is an essential strategy to protect human health from pathogens
and prevent their regrowth during water distribution, but the reaction of disinfectant agents …

As a result of technical advances in recombinant DNA technology and nucleotide
sequencing, entire genome sequences have become available in the past decade and offer …

Continual nitric oxide (NO) synthesis is important in the regulation of vascular tone and thus
blood pressure. Whereas classically NO is provided by the enzymatic oxidation of l-arginine …

Cytochrome P450 monooxygenases of the CYP2A subfamily play important roles in
xenobiotic disposition in the liver and in metabolic activation in extrahepatic tissues. Many of …