Reelin functions, mechanisms of action and signaling pathways during brain development and maturation

Y Jossin - Biomolecules, 2020 - mdpi.com
During embryonic development and adulthood, Reelin exerts several important functions in
the brain including the regulation of neuronal migration, dendritic growth and branching …

[HTML][HTML] Trekking across the brain: the journey of neuronal migration

R Ayala, T Shu, LH Tsai - Cell, 2007 - cell.com
The correct positioning of neurons during development—achieved through directed
migration—is the basis for proper brain function. Several decades of research have yielded …

Mechanism suppressing glycogen synthesis in neurons and its demise in progressive myoclonus epilepsy

D Vilchez, S Ros, D Cifuentes, L Pujadas, J Vallès… - Nature …, 2007 - nature.com
Glycogen synthesis is normally absent in neurons. However, inclusion bodies resembling
abnormal glycogen accumulate in several neurological diseases, particularly in progressive …

Reelin regulates postnatal neurogenesis and enhances spine hypertrophy and long-term potentiation

L Pujadas, A Gruart, C Bosch, L Delgado… - Journal of …, 2010 - Soc Neuroscience
Reelin, an extracellular protein essential for neural migration and lamination, is also
expressed in the adult brain. To unravel the function of this protein in the adult forebrain, we …

Cell migration in the normal and pathological postnatal mammalian brain

M Cayre, P Canoll, JE Goldman - Progress in neurobiology, 2009 - Elsevier
In the developing brain, cell migration is a crucial process for structural organization, and is
therefore highly regulated to allow the correct formation of complex networks, wiring …

Canonical and non-canonical reelin signaling

HH Bock, P May - Frontiers in cellular neuroscience, 2016 - frontiersin.org
Reelin is a large secreted glycoprotein that is essential for correct neuronal positioning
during neurodevelopment and is important for synaptic plasticity in the mature brain …

BDNF/TrkB interaction regulates migration of SVZ precursor cells via PI3‐K and MAP‐K signalling pathways

S Chiaramello, G Dalmasso, L Bezin… - European Journal of …, 2007 - Wiley Online Library
Neuroblasts born in the subventricular zone (SVZ) migrate along the rostral migratory
stream, reaching the olfactory bulb (OB) where they differentiate into local interneurons …

IGF‐I promotes neuronal migration and positioning in the olfactory bulb and the exit of neuroblasts from the subventricular zone

A Hurtado‐Chong, MJ Yusta‐Boyo… - European Journal of …, 2009 - Wiley Online Library
While insulin‐like growth factor‐I (IGF‐I) supports neuronal and glial differentiation in the
CNS, it is largely unknown whether IGF‐I also influences neuronal migration and …

Neural ECM molecules in synaptic plasticity, learning, and memory

O Senkov, P Andjus, L Radenovic, E Soriano… - Progress in brain …, 2014 - Elsevier
Neural extracellular matrix (ECM) molecules derived from neurons and glial cells
accumulate in the extracellular space and regulate synaptic plasticity through modulation of …

Reelin regulates the maturation of dendritic spines, synaptogenesis and glial ensheathment of newborn granule cells

C Bosch, N Masachs, D Exposito-Alonso… - Cerebral …, 2016 - academic.oup.com
The Reelin pathway is essential for both neural migration and for the development and
maturation of synaptic connections. However, its role in adult synaptic formation and …