GPCR interactions involving metabotropic glutamate receptors and their relevance to the pathophysiology and treatment of CNS disorders
F Nicoletti, L Di Menna, L Iacovelli, R Orlando… - …, 2023 - Elsevier
Cellular responses to metabotropic glutamate (mGlu) receptor activation are shaped by
mechanisms of receptor-receptor interaction. mGlu receptor subtypes form homodimers …
mechanisms of receptor-receptor interaction. mGlu receptor subtypes form homodimers …
Targeting diacylglycerol lipase reduces alcohol consumption in preclinical models
ND Winters, G Bedse, AA Astafyev… - The Journal of …, 2021 - Am Soc Clin Investig
Alcohol use disorder (AUD) is associated with substantial morbidity, mortality, and societal
cost, and pharmacological treatment options are limited. The endogenous cannabinoid …
cost, and pharmacological treatment options are limited. The endogenous cannabinoid …
Adolescent alcohol exposure produces sex differences in negative affect-like behavior and group I mGluR BNST plasticity
CR Kasten, KL Carzoli, NM Sharfman… - …, 2020 - nature.com
Adolescent alcohol exposure increases the risk of developing alcohol use disorders (AUDs),
yet the mechanisms responsible for this vulnerability remain largely unknown. One potential …
yet the mechanisms responsible for this vulnerability remain largely unknown. One potential …
Allosteric modulation of metabotropic glutamate receptors in alcohol use disorder: Insights from preclinical investigations
KA Johnson, DM Lovinger - Advances in Pharmacology, 2020 - Elsevier
Metabotropic glutamate (mGlu) receptors are family CG protein-coupled receptors (GPCRs)
that modulate neuronal excitability and synaptic transmission throughout the nervous …
that modulate neuronal excitability and synaptic transmission throughout the nervous …
Increased Synaptic Strength and mGlu2/3 Receptor Plasticity on Mouse Prefrontal Cortex Intratelencephalic Pyramidal Cells Following Intermittent Access to Ethanol
Background The medial prefrontal cortex (PFC) is crucial for regulating craving and alcohol
seeking in alcohol use disorder (AUD) patients and alcohol seeking in animal models …
seeking in alcohol use disorder (AUD) patients and alcohol seeking in animal models …
Parvalbumin interneuron mGlu5 receptors govern sex differences in prefrontal cortex physiology and binge drinking
CB Fabian, ND Jordan, RH Cole, LG Carley… - …, 2024 - nature.com
Despite established sex differences in the prevalence and presentation of psychiatric
disorders, little is known about the cellular and synaptic mechanisms that guide these …
disorders, little is known about the cellular and synaptic mechanisms that guide these …
BNST specific mGlu5 receptor knockdown regulates sex-dependent expression of negative affect produced by adolescent ethanol exposure and adult stress
CR Kasten, EB Holmgren, MR Lerner… - Translational Psychiatry, 2021 - nature.com
Adolescent alcohol use is one of the strongest predictors for the development of an alcohol
use disorder (AUD). Notably, this period of risk coincides with the development of affective …
use disorder (AUD). Notably, this period of risk coincides with the development of affective …
The infralimbic cortex and mGlu5 mediate the effects of chronic intermittent ethanol exposure on fear learning and memory
CE Smiley, JT McGonigal, T Valvano, RJ Newsom… - …, 2020 - Springer
Rationale and objectives Alcohol use disorder (AUD) and post-traumatic stress disorder
(PTSD) often occur comorbidly. While the incidence of these disorders is increasing, there is …
(PTSD) often occur comorbidly. While the incidence of these disorders is increasing, there is …
[HTML][HTML] Altered Expression of Neuroplasticity-Related Genes in Alcohol Addiction and Treatment
E Legaki, N Dovrolis, N Moscholiou… - International Journal of …, 2024 - mdpi.com
Alcohol use disorder's complexity arises from genetic and environmental factors, with
alcohol metabolism genes and neurotransmitter pathways being critical. This study aims to …
alcohol metabolism genes and neurotransmitter pathways being critical. This study aims to …
An inpatient human laboratory study assessing the safety and tolerability, pharmacokinetics, and biobehavioral effect of GET 73 when co-administered with alcohol in …
CL Haass-Koffler, R Perciballi, M Magill, A Loche… - …, 2022 - Springer
Rationale Previous work suggests that GET 73, a novel compound with putative activity on
the metabotropic glutamate receptor subtype 5 (mGluR5), may represent a novel …
the metabotropic glutamate receptor subtype 5 (mGluR5), may represent a novel …