Recent Advancements in Refashioning of NSAIDs and their Derivatives as Anticancer Candidates

AE Kassab, EM Gedawy - Current Pharmaceutical Design, 2024 - benthamdirect.com
Inflammation is critical to the formation and development of tumors and is closely associated
with cancer. Therefore, addressing inflammation and the mediators that contribute to the …

Novel N-Acyl Hydrazone Compounds as Promising Anticancer Agents: Synthesis and Molecular Docking Studies

Y Biliz, B Hasdemir, H Başpınar Küçük… - ACS …, 2023 - ACS Publications
In this study, a new series of N-acyl hydrazones 7a-e, 8a-e, and 9a-e, starting from methyl δ-
oxo pentanoate with different substituted groups 1a-e, were synthesized as anticancer …

Investigation on hydrazonobenzenesulfonamides as human carbonic anhydrase I, II, IX and XII inhibitors

D Moi, S Vittorio, A Angeli, G Balboni, CT Supuran… - Molecules, 2022 - mdpi.com
A small series of hydrazonobenzenesulfonamides was designed, synthesized and studied
for their human carbonic anhydrase (hCA) inhibitory activity. The synthesized compounds …

Synthesis, antimicrobial properties and in silico studies of aryloxyacetic acid derivatives with hydrazone or thiazolidine-4-one scaffold

S Şenkardeş, D Kart, B Bebek, MG Gündüz… - Journal of …, 2023 - Taylor & Francis
In this work, twenty hydrazide-hydrazone and 4-thiazolidinone derivatives were synthesized
starting from m-cresol. Antimicrobial evaluation was carried out by microdilution method …

Novel 2, 4-Dichloro-5-sulfamoylbenzoic Acid Oxime Esters: First Studies as Potential Human Carbonic Anhydrase Inhibitors

JT Kilbile, SB Sapkal, G Renzi… - ACS Medicinal …, 2024 - ACS Publications
In this study, a focused library of oxime ester derivatives of 2, 4-dichloro-5-sulfamoylbenzoic
acid (lasamide) containing Schiff bases was synthesized and tested in vitro for their ability to …

Synthesis and Evaluation of Novel Metacetamol Derivatives with Hydrazone Moiety as Anticancer and Antimicrobial Agents

S Şenkardeş, İ Atlıhan, E Çayır… - Chemistry & …, 2023 - Wiley Online Library
By exploiting the wide biological potential of the hydrazone scaffold, a series of hydrazone
derivatives were synthesized, starting from N‐(3‐hydroxyphenyl) acetamide (metacetamol) …

Synthesis, Structure Elucidation and Biological Activity of New Hybrid Hydrazone-Amide Compounds

G Coşkun, A Aklamuz, U İnce… - Cumhuriyet Science …, 2022 - csj.cumhuriyet.edu.tr
Bacterial infection today occupies a tremendous place in world health. The infection
diseases were kept under control after the development of penicillin and further studies were …

Synthesis and biological evaluation of new 4-thiazolidinone derivatives of flurbiprofen

P Suzgun, S Şenkardeş, M Gurboga… - Organic …, 2023 - avesis.marmara.edu.tr
In this study, the synthesis and characterization of 2-(2-fluorobiphenyl-4-yl)-N'-[(substituted
methylene] propanehydrazides (3a-s) and 2-(2-fluoro-[1, 1'-biphenyl]-4-yl)-N-(5-methyl-2 …

Synthesis and Antibacterial Activity of Some Aryloxyacetic Acid Derivatives Containing Aryl Sulfonate Moiety

S Şenkardeş, T Koyuncu, HB Erol… - Online Turkish Journal …, 2023 - dergipark.org.tr
Amaç: Günümüzde antibiyotik direnci gelişimi hızla artmaktadır. Bu da yeni antibiyotiklerin
keşfedilmesini gerekli kılmaktadır. Dolayısıyla bu araştırmanın amacı yeni antibakteriyel …