Rewriting the genetic code
The genetic code—the language used by cells to translate their genomes into proteins that
perform many cellular functions—is highly conserved throughout natural life. Rewriting the …
perform many cellular functions—is highly conserved throughout natural life. Rewriting the …
Biochemistry of fluoroprolines: The prospect of making fluorine a bioelement
V Kubyshkin, R Davis, N Budisa - Beilstein journal of organic …, 2021 - beilstein-journals.org
Due to the heterocyclic structure and distinct conformational profile, proline is unique in the
repertoire of the 20 amino acids coded into proteins. Here, we summarize the biochemical …
repertoire of the 20 amino acids coded into proteins. Here, we summarize the biochemical …
Coevolution theory of the genetic code at age forty: pathway to translation and synthetic life
The origins of the components of genetic coding are examined in the present study. Genetic
information arose from replicator induction by metabolite in accordance with the metabolic …
information arose from replicator induction by metabolite in accordance with the metabolic …
Chemical evolution of a bacterial proteome
MG Hoesl, S Oehm, P Durkin, E Darmon… - Angewandte Chemie …, 2015 - Wiley Online Library
We have changed the amino acid set of the genetic code of Escherichia coli by evolving
cultures capable of growing on the synthetic noncanonical amino acid l‐β‐(thieno [3, 2‐b] …
cultures capable of growing on the synthetic noncanonical amino acid l‐β‐(thieno [3, 2‐b] …
Multiomics Analysis Provides Insight into the Laboratory Evolution of Escherichia coli toward the Metabolic Usage of Fluorinated Indoles
F Agostini, L Sinn, D Petras, CJ Schipp… - ACS Central …, 2020 - ACS Publications
Organofluorine compounds are known to be toxic to a broad variety of living beings in
different habitats, and chemical fluorination has been historically exploited by mankind for …
different habitats, and chemical fluorination has been historically exploited by mankind for …
In vivo, in vitro and in silico: an open space for the development of microbe‐based applications of synthetic biology
A Danchin - Microbial Biotechnology, 2022 - Wiley Online Library
Living systems are studied using three complementary approaches: living cells, cell‐free
systems and computer‐mediated modelling. Progresses in understanding, allowing …
systems and computer‐mediated modelling. Progresses in understanding, allowing …
Adaptive properties of the genetically encoded amino acid alphabet are inherited from its subsets
Life uses a common set of 20 coded amino acids (CAAs) to construct proteins. This set was
likely canonicalized during early evolution; before this, smaller amino acid sets were …
likely canonicalized during early evolution; before this, smaller amino acid sets were …
Alternative biochemistries for alien life: basic concepts and requirements for the design of a robust biocontainment system in genetic isolation
C Diwo, N Budisa - Genes, 2018 - mdpi.com
The universal genetic code, which is the foundation of cellular organization for almost all
organisms, has fostered the exchange of genetic information from very different paths of …
organisms, has fostered the exchange of genetic information from very different paths of …
Evolving a mitigation of the stress response pathway to change the basic chemistry of life
I Tolle, S Oehm, MG Hoesl… - Frontiers in Synthetic …, 2023 - frontiersin.org
Despite billions of years of evolution, there have been only minor changes in the number
and types of proteinogenic amino acids and the standard genetic code with codon …
and types of proteinogenic amino acids and the standard genetic code with codon …
Efforts and challenges in engineering the genetic code
This year marks the 48th anniversary of Francis Crick's seminal work on the origin of the
genetic code, in which he first proposed the “frozen accident” hypothesis to describe …
genetic code, in which he first proposed the “frozen accident” hypothesis to describe …