AKI is a common complication of sepsis and is significantly associated with mortality. Sepsis
accounts for more than 50% of the cases of AKI, with a mortality rate of up to 40%. The …

Perioperative hypotension is common and associated with poor outcomes, including acute
kidney injury (AKI). The mechanistic link between perioperative hypotension and AKI is at …

Glomerular filtration rate (GFR) is acutely increased following a high-protein meal or
systemic infusion of amino acids. The mechanisms underlying this renal functional response …

Sepsis is the leading cause of acute kidney injury (AKI) and leads to increased morbidity
and mortality in intensive care units. Current treatments for septic AKI are largely supportive …

This is a narrative review of recent articles (mainly published in 2017 and 2018) related to
the conduct of cardiopulmonary bypass (CPB) that should be of interest to the cardiac …

Background Acute kidney injury (AKI) is common after cardiac surgery and profoundly
affects postoperative mortality and morbidity. There are no validated methods to assess risk …

Renal medullary hypoxia may contribute to cardiac surgery–associated acute kidney injury
(AKI). However, the effects of cardiopulmonary bypass (CPB) on medullary oxygenation are …

Background Acute kidney injury (AKI) is a common and serious complication after cardiac
surgery, and current strategies aimed at treating AKI have proven ineffective. Levosimendan …

Agonists of α2‐adrenoceptors are increasingly being used for the provision of comfort,
sedation and the management of delirium in critically ill patients, with and without sepsis. In …

Histone deacetylases (HDACs) are part of the epigenetic machinery that regulates
transcriptional processes. The current paradigm is that HDACs silence gene expression via …