The involvement of innate and adaptive immunity in the initiation and perpetuation of sjögren's syndrome
C Chivasso, J Sarrand, J Perret, C Delporte… - International journal of …, 2021 - mdpi.com
Sjogren's syndrome (SS) is a chronic autoimmune disease characterized by the infiltration of
exocrine glands including salivary and lachrymal glands responsible for the classical dry …
exocrine glands including salivary and lachrymal glands responsible for the classical dry …
Humanized mouse models: Application to human diseases
R Ito, T Takahashi, M Ito - Journal of cellular physiology, 2018 - Wiley Online Library
Humanized mice are superior to rodents for preclinical evaluation of the efficacy and safety
of drug candidates using human cells or tissues. During the past decade, humanized mouse …
of drug candidates using human cells or tissues. During the past decade, humanized mouse …
Systemic human ILC precursors provide a substrate for tissue ILC differentiation
Innate lymphoid cells (ILCs) represent innate versions of T helper and cytotoxic T cells that
differentiate from committed ILC precursors (ILCPs). How ILCPs give rise to mature tissue …
differentiate from committed ILC precursors (ILCPs). How ILCPs give rise to mature tissue …
Group 3 innate lymphoid cell pyroptosis represents a host defence mechanism against Salmonella infection
Group 3 innate lymphoid cells (ILC3s) produce interleukin (IL)-22 and coordinate with other
cells in the gut to mount productive host immunity against bacterial infection. However, the …
cells in the gut to mount productive host immunity against bacterial infection. However, the …
Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition
A recombinant vaccine containing Aventis Pasteur's canarypox vector (ALVAC)–HIV and
gp120 alum decreased the risk of HIV acquisition in the RV144 vaccine trial. The substitution …
gp120 alum decreased the risk of HIV acquisition in the RV144 vaccine trial. The substitution …
Gut mucosal barrier dysfunction, microbial dysbiosis, and their role in HIV-1 disease progression
JC Mudd, JM Brenchley - The Journal of infectious diseases, 2016 - academic.oup.com
Distinct pathological events occur within the gastrointestinal (GI) tract of Asian macaques
with progressive simian immunodeficiency virus (SIV) infection and humans with human …
with progressive simian immunodeficiency virus (SIV) infection and humans with human …
[HTML][HTML] Blocking type I interferon signaling enhances T cell recovery and reduces HIV-1 reservoirs
Chronic immune activation, immunosuppression, and T cell exhaustion are hallmarks of HIV
infection, yet the mechanisms driving these processes are unclear. Chronic activation can …
infection, yet the mechanisms driving these processes are unclear. Chronic activation can …
Innate lymphoid cells are depleted irreversibly during acute HIV-1 infection in the absence of viral suppression
Innate lymphoid cells (ILCs) play a central role in the response to infection by secreting
cytokines crucial for immune regulation, tissue homeostasis, and repair. Although …
cytokines crucial for immune regulation, tissue homeostasis, and repair. Although …
Compartment-specific distribution of human intestinal innate lymphoid cells is altered in HIV patients under effective therapy
B Krämer, F Goeser, P Lutz, A Glässner… - PLoS …, 2017 - journals.plos.org
Innate lymphocyte cells (ILCs), a novel family of innate immune cells are considered to
function as key orchestrators of immune defences at mucosal surfaces and to be crucial for …
function as key orchestrators of immune defences at mucosal surfaces and to be crucial for …
Epigenetic regulator CXXC5 recruits DNA demethylase Tet2 to regulate TLR7/9-elicited IFN response in pDCs
TLR7/9 signals are capable of mounting massive interferon (IFN) response in plasmacytoid
dendritic cells (pDCs) immediately after viral infection, yet the involvement of epigenetic …
dendritic cells (pDCs) immediately after viral infection, yet the involvement of epigenetic …