Amyotrophic lateral sclerosis (ALS) is a devastating disease caused by degeneration of
motor neurons. As with all major neurodegenerative disorders, development of disease …

Although the past two decades have produced exciting discoveries in the genetics and
pathology of amyotrophic lateral sclerosis (ALS), progress in developing an effective therapy …

Objective To unveil clinical features, comorbidities, disease progression and prognostic
factors in a population-based cohort of ALS patients carrying C9ORF72 expansion (C9+ …

Neurofilament levels are elevated in many neurodegenerative diseases and have shown
promise as diagnostic and prognostic biomarkers in Amyotrophic Lateral Sclerosis (ALS) …

Background This study aimed at (1) delivering generalizable estimates of the prevalence of
frontotemporal-spectrum disorders (FTSDs) in non-demented ALS patients and (2) exploring …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterised by
functional connectivity alterations in both motor and extra-motor brain regions. Within the …

Objective To determine the average time from Amyotrophic Lateral Sclerosis (ALS) symptom
onset to 11 pre-defined milestones, overall and according to ALS progression rate and …

BACKGROUND AND PURPOSE: The previous studies described phenotype-associated
imaging findings in amyotrophic lateral sclerosis (ALS) with a prior categorization of patients …

Objective: Levels of chitotriosidase (CHIT1) are increased in the cerebrospinal fluid (CSF) of
amyotrophic lateral sclerosis (ALS) patients reflecting microglial activation. Here, we …

Background: Assessing clinical progression in amyotrophic lateral sclerosis (ALS) remains a
challenge. We evaluated the validity and predictive capabilities of the King's and Milano …