The biological applications of DNA nanomaterials: current challenges and future directions

W Ma, Y Zhan, Y Zhang, C Mao, X Xie… - Signal transduction and …, 2021 - nature.com
DNA, a genetic material, has been employed in different scientific directions for various
biological applications as driven by DNA nanotechnology in the past decades, including …

Challenges and perspectives of DNA nanostructures in biomedicine

A Keller, V Linko - Angewandte Chemie International Edition, 2020 - Wiley Online Library
DNA nanotechnology holds substantial promise for future biomedical engineering and the
development of novel therapies and diagnostic assays. The subnanometer‐level …

DNA nanostructures: current challenges and opportunities for cellular delivery

A Lacroix, HF Sleiman - ACS nano, 2021 - ACS Publications
DNA nanotechnology has produced a wide range of self-assembled structures, offering
unmatched possibilities in terms of structural design. Because of their programmable …

Engineering nucleic acid structures for programmable molecular circuitry and intracellular biocomputation

J Li, AA Green, H Yan, C Fan - Nature chemistry, 2017 - nature.com
Nucleic acids have attracted widespread attention due to the simplicity with which they can
be designed to form discrete structures and programmed to perform specific functions at the …

Control of polymeric nanoparticle size to improve therapeutic delivery

JW Hickey, JL Santos, JM Williford, HQ Mao - Journal of Controlled …, 2015 - Elsevier
As nanoparticle (NP)-mediated drug delivery research continues to expand, understanding
parameters that govern NP interactions with the biological environment becomes …

DNA nanotechnology-empowered nanoscopic imaging of biomolecules

F Li, J Li, B Dong, F Wang, C Fan, X Zuo - Chemical Society Reviews, 2021 - pubs.rsc.org
Advances in bioimaging technologies have led to unprecedented findings of novel
biological processes at the nanoscale. However, there remains an ever-lasting demand for …

Programmable and multifunctional DNA‐based materials for biomedical applications

Y Zhang, J Tu, D Wang, H Zhu, SK Maity… - Advanced …, 2018 - Wiley Online Library
DNA encodes the genetic information; recently, it has also become a key player in material
science. Given the specific Watson–Crick base‐pairing interactions between only four types …

DNA nanostructures at the interface with biology

KE Bujold, A Lacroix, HF Sleiman - Chem, 2018 - cell.com
Over the past four decades, the field of structural DNA nanotechnology has evolved into an
accessible approach to generating DNA nanostructures with precise control of size …

Uptake and fate of fluorescently labeled DNA nanostructures in cellular environments: a cautionary tale

A Lacroix, E Vengut-Climent… - ACS central …, 2019 - ACS Publications
Fluorescent dye labeling of DNA oligonucleotides and nanostructures is one of the most
used techniques to track their fate and cellular localization inside cells. Here, we report that …

Rationally programming nanomaterials with DNA for biomedical applications

L He, J Mu, O Gang, X Chen - Advanced Science, 2021 - Wiley Online Library
DNA is not only a carrier of genetic information, but also a versatile structural tool for the
engineering and self‐assembling of nanostructures. In this regard, the DNA template has …