[HTML][HTML] Targeting the tumor microenvironment: Potential strategy for cancer therapeutics

Q Babar, A Saeed, TA Tabish, M Sarwar… - Biochimica et Biophysica …, 2023 - Elsevier
Cellular and stromal components including tumor cells, immune cells, mesenchymal cells,
cancer-linked fibroblasts, and extracellular matrix, constituent tumor microenvironment …

Hypoxia within the glioblastoma tumor microenvironment: a master saboteur of novel treatments

L Feldman - Frontiers in Immunology, 2024 - frontiersin.org
Glioblastoma (GBM) tumors are the most aggressive primary brain tumors in adults that,
despite maximum treatment, carry a dismal prognosis. GBM tumors exhibit tissue hypoxia …

Evolution of cell therapy for renal cell carcinoma

Y Wang, ER Suarez, G Kastrunes, NSP de Campos… - Molecular Cancer, 2024 - Springer
Abstract Treatment for renal cell carcinoma (RCC) has improved dramatically over the last
decade, shifting from high-dose cytokine therapy in combination with surgical resection of …

Click chemistry approaches for developing carbonic anhydrase inhibitors and their applications

A Angeli, CT Supuran - Journal of Enzyme Inhibition and Medicinal …, 2023 - Taylor & Francis
Click chemistry reactions constitute an important and relatively new approach in the
medicinal chemistry toolbox and offer substantial advantages to medicinal chemists in terms …

Molecular Imaging Diagnosis of Renal Cancer Using 99mTc-Sestamibi SPECT/CT and Girentuximab PET-CT-Current Evidence and Future Development of Novel …

OS Tataru, M Marchioni, F Crocetto, B Barone… - Diagnostics, 2023 - mdpi.com
Novel molecular imaging opportunities to preoperatively diagnose renal cell carcinoma is
under development and will add more value in limiting the postoperative renal function loss …

Combined Ultrasensitive Detection of Renal Cancer Proteins and Cells Using an Optical Microfiber Functionalized with Ti3C2 MXene and Gold Nanorod …

H Li, T Huang, H Yuan, L Lu, Z Cao, L Zhang… - Analytical …, 2023 - ACS Publications
The ultrasensitive and quantitative detection of renal cancer protein biomarkers present at
ultralow concentrations for early-stage cancer diagnosis requires a biosensing probe …

Design, synthesis and mechanism study of coumarin-sulfonamide derivatives as carbonic anhydrase IX inhibitors with anticancer activity

Q Lv, J Zhang, J Cai, L Chen, J Liang, T Zhang… - Chemico-Biological …, 2024 - Elsevier
In this study, twenty-nine coumarin-3-sulfonamide derivatives, twenty-seven of which are
original were designed and synthesized. Cytotoxicity assay indicated that most of these …

Peptide vaccines as therapeutic and prophylactic agents for female-specific cancers: the current landscape

M Lekshmy, CR Dhanya, JSK Smrithi, JA Sindhurani… - Pharmaceuticals, 2023 - mdpi.com
Breast and gynecologic cancers are significant global threats to women's health and those
living with the disease require lifelong physical, financial, and social support from their …

Immune Checkpoint Blockade via PD-L1 Potentiates More CD28-Based than 4-1BB-Based Anti-Carbonic Anhydrase IX Chimeric Antigen Receptor T Cells

NSP de Campos, A de Oliveira Beserra… - International Journal of …, 2022 - mdpi.com
The complete regression of clear cell renal cell carcinoma (ccRCC) obtained pre-clinically
with anti-carbonic anhydrase IX (CAIX) G36 chimeric antigen receptor (CAR) T cells in …

In silico and in vitro study of bioactive compounds of Nigella sativa for targeting neuropilins in breast cancer

I Zafar, A Safder, H Imran Afridi, S Riaz… - Frontiers in …, 2023 - frontiersin.org
Introduction: Breast cancer poses a significant global challenge, prompting researchers to
explore novel approaches for potential treatments. Material and Methods: For in vitro study …